Tryptamine antagonists and punished behavior.
Tryptamine antagonists and punished behavior.
复制标题
色胺拮抗剂和惩罚行为。
DOI：
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发表时间：
1974
影响因子：
3.5
通讯作者：
F. Graeff
中科院分区：
文献类型：
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作者：
F. Graeff
研究了两种色胺拮抗剂甲塞吉胺和赛庚啶对大鼠杠杆按压行为的量效关系。采用同步固定间隔1分钟的水、固定比例5次的电击惩罚方案。由于赛庚啶具有抗组胺和抗毒蕈碱的作用，测定了阿托品与苯海拉明、吡咯胺和HS-592三种抗组胺药物的剂量-反应曲线。同时还考察了不同剂量的小剂量镇静剂、氯二氮环氧化物和戊巴比妥对惩罚行为的影响。适当剂量的甲塞吉特、赛庚啶、氯二氮环氧化物、戊巴比妥和阿托品可提高惩罚抑制的反应率。在同一动物组中，使用5.6 mg/kg的赛庚啶可将平均反应率提高至对照组的218%，而使用3 mg/kg的甲塞吉胺可使平均反应率提高163%，使用5.6 mg/kg的氯二氮环氧化物可使平均反应率提高248%。戊巴比妥10 mg/kg的剂量使这组大鼠的平均反应率提高到对照组的192%，另一组大鼠的平均反应率提高到212%。在给予1 - 10mg /kg阿托品后，平均缓解率（最大为对照的136%）有微小但可测量的增加。相比之下，三种抗组胺药只对惩罚反应产生降低率的作用。这些结果表明，色胺拮抗剂通过干扰大脑中参与行为抑制的色胺能机制来提高受惩罚抑制的反应率。
The dose-effect relationships of two tryptamine antagonists, methysergide and cyproheptadine, on lever-pressing behavior of rats were determined. A concurrent fixedinterval 1 minute water, fixed-ratio 5 electric shock punishment schedule was used. Since cyproheptadine shows antihistaminic as well as antimuscarinic actions, dose-response curves for atropine and the three antihistaminic drugs, diphenhydramine, pyrilamine and HS-592, on punished responding were determined. The effects of selected doses of the minor tranquilizers, chlordiazepoxide and pentobarbital on punished performance were also measured. Appropriate doses of methysergide, cyproheptadine, chlordiazepoxide, pentobarbital and atropine increased response rates suppressed by punishment. The mean response rate was maximally increased to 218% of control by 5.6 mg/kg of cyproheptadine, as compared to 163% for methysergide (3 mg/kg) and the 248% rate increase caused by 5.6 mg/kg of clordiazepoxide in the same animal group. The dose of 10 mg/kg of pentobarbital increased the mean response rate to 192% of control in this group of rats and 212% in another. Small, but measurable, increases in mean response rate (maximum 136% of control) followed the administration of 1 to 10 mg/kg of atropine. In contrast, the three antihistaminics caused only rate-decreasing effects on punished responding. These results suggest that tryptamine antagonists increase response rates suppressed by punishment by interfering with a tryptaminergic mechanism in brain involved in behavioral inhibition.