Validation of attenuation-corrected equilibrium radionuclide angiographic determinations of right ventricular volume: comparison with cast-validated biplane cineventriculography.
Validation of attenuation-corrected equilibrium radionuclide angiographic determinations of right ventricular volume: comparison with cast-validated biplane cineventriculography.
复制标题
右心室体积的衰减校正平衡放射性核素血管造影测定的验证：与模型验证的双平面电影心室造影的比较。
DOI：
10.1161/01.cir.72.2.317
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发表时间：
1985
期刊：
影响因子：
37.8
通讯作者：
Blumhardt,R
中科院分区：
文献类型：
--
作者：
Dell'Italia,LJ;Starling,MR;Walsh,RA;Badke,FR;Lasher,JC;Blumhardt,R
为了确定衰减校正平衡放射性核素血管造影测定右室容量的准确性，我们初步研究了14例人死后右室模型的水置换和双平面脑室造影。经改进的Simpson规则算法计算的双平面脑室造影右室管型体积与水位移法测量的右室管型体积有很好的相关性(r=0.97，y=8+0.88x，SEE=6ml)。两种方法测得的平均体积分别为73+/-28ml和73+/-25ml。随后，我们对16例患者进行了双平面脑室造影和平衡核素血管造影。未校正的放射性核素右室容量是通过归一化背景校正的舒张末和收缩末期计数来计算的，这些背景校正来自手绘的感兴趣区域，通过对处理的心动周期、帧频率和血样计数进行相位分析而获得。衰减校正用一种简单的几何方法进行。经衰减校正的放射性核素右室舒张末容积与室壁造影的舒张末容积呈正相关(r=0.91，y=3+0.92x，SEE=27ml)。同样，衰减校正的放射性核素右室收缩末期容量与脑室造影的收缩末期容量相关(r=0.93，y=-1+0.91x，SEE=16ml)。此外，平均衰减校正的放射性核素舒张期和收缩末期容量与脑室造影的平均舒张期和收缩末期容量(分别为160+/-61和83+/-44比170+/-61和86+/-43毫升)无差异。对比未校正和衰减校正的放射性核素右室容量，在大范围的脑室摄影体积上，经注意校正的右室容量测定的95%可信区间较窄。因此，我们得出的结论是：(1)经衰减校正的放射性核素右室舒张末和收缩末期容量与管型验证的双平面电影摄影方法得到的右室容量比较接近；(2)经衰减校正的放射性核素右室容量与双平面电影摄影右室容量的测定更接近，因此可能比未经校正的放射性核素右室容量更准确。
To determine the accuracy of attenuation-corrected equilibrium radionuclide angiographic determinations of right ventricular volumes, we initially studied 14 postmortem human right ventricular casts by water displacement and biplane cineventriculography. Biplane cineventriculographic right ventricular cast volumes, calculated by a modification of Simpson's rule algorithm, correlated well with right ventricular cast volumes measured by water displacement (r = .97, y = 8 + 0.88x, SEE = 6 ml). Moreover, the mean volumes obtained by both methods were no different (73 +/- 28 vs 73 +/- 25 ml). Subsequently, we studied 16 patients by both biplane cineventriculography and equilibrium radionuclide angiography. The uncorrected radionuclide right ventricular volumes were calculated by normalizing background corrected end-diastolic and end-systolic counts from hand-drawn regions of interest obtained by phase analysis for cardiac cycles processed, frame rate, and blood sample counts. Attenuation correction was performed by a simple geometric method. The attenuation-corrected radionuclide right ventricular end-diastolic volumes correlated with the cineventriculographic end-diastolic volumes (r = .91, y = 3 + 0.92x, SEE = 27 ml). Similarly, the attenuation-corrected radionuclide right ventricular end-systolic volumes correlated with the cineventriculographic end-systolic volumes (r = .93, y = - 1 + 0.91x, SEE = 16 ml). Also, the mean attenuation-corrected radionuclide end-diastolic and end-systolic volumes were no different than the average cineventriculographic end-diastolic and end-systolic volumes (160 +/- 61 and 83 +/- 44 vs 170 +/- 61 and 86 +/- 43 ml, respectively). Comparison of the uncorrected and attenuation-corrected radionuclide right ventricular volumes demonstrated narrower 95% confidence intervals for the attentuation-corrected right ventricular volume determinations over a wide range of cineventriculographic volumes. Thus we conclude that: (1) attenuation-corrected radionuclide right ventricular end-diastolic and end-systolic volumes compare closely with those obtained by a cast-validated biplane cineventriculographic method and (2) attenuation-corrected radionuclide right ventricular volumes correspond more closely to determinations of biplane cineventriculographic right ventricular volumes and are thus likely to be more accurate than uncorrected radionuclide right ventricular volumes.