Cold-rearing normalizes capacity for norepinephrine-stimulated thermogenesis but not body temperature in 16-day-old fatty Zucker rats.
Cold-rearing normalizes capacity for norepinephrine-stimulated thermogenesis but not body temperature in 16-day-old fatty Zucker rats.
复制标题
冷饲养可以使去甲肾上腺素刺激的产热能力正常化，但不能使 16 日龄的脂肪 Zucker 大鼠的体温正常化。
DOI：
10.1016/0024-3205(86)90004-4
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发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Carlisle,HJ
中科院分区：
文献类型：
--
作者：
Schmidt,I;Stahl,J;Kaul,R;Carlisle,HJ
研究了降低饲养温度对16 ~ 17日龄Zucker大鼠幼鼠体重、体核温度（Tc）和去甲肾上腺素（NE）刺激产热的影响。在18°C（“冷饲养”）条件下饲养的16日龄肥仔明显比瘦仔重9%，而在25°C（“正常饲养”）条件下饲养的16日龄肥仔则不然。在25℃下隔离2 h后，冷饲养的瘦肉幼仔的Tc（37.1℃）略高于正常饲养的幼崽（36.4℃），而在两种温度下饲养的脂肪幼仔则严重低温（Tc = 33 ~ 34℃）。在环境温度为25℃时，皮下注射800 μg/kg NE后，脂肪和瘦肉冷养幼崽的体温升高至39.5℃。正常饲养的瘦肉型幼崽注射NE后的Tc峰值与正常饲养的瘦肉型幼崽相同，而脂肪型幼崽的Tc峰值明显较低，为38.4°C。与哺乳期肥胖Zucker大鼠过量脂肪沉积相关的低体温不是由ne刺激产热能力降低引起的。
The effects of a lowered rearing temperature on body weight, core temperature (Tc) and norepinephrine(NE)-stimulated thermogenesis were investigated in 16- to 17-day-old Zucker rat pups. 16-day-old fatty pups were significantly heavier (9%) than lean littermates in litters reared at 18°C (“cold-reared”) but not in litters reared at 25°C (“normally-reared”). After 2 h isolation at 25°C, Tc of lean pups was slightly higher (37.1°C) in cold-reared litters than in normally-reared litters (36.4°C), while fatty pups reared at either temperature were severely hypothermic (Tc = 33 – 34°C). At an ambient temperature of 25°C Tc in fatty and lean cold-reared pups increased to 39.5°C after subcutaneous injection of 800 μg/kg NE. Normally-reared lean pups reached the same peak Tc after NE injection, while their fatty littermates reached a significantly lower peak Tc of 38.4°C. The hypothermia associated with the onset of excess fat deposition in suckling fatty Zucker rats is not caused by a reduced capacity for NE-stimulated thermogenesis.