Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects
Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects
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DOI：
10.1192/bjp.bp.113.134452
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发表时间：
2014-05-01
影响因子：
10.5
通讯作者：
Hatch, Stephani L.
中科院分区：
文献类型：
--
作者：
Morgan, Craig;Reininghaus, Ulrich;Hatch, Stephani L.
背景有充分的证据表明，童年逆境与精神病的风险增加有关。然而，很少有研究干预因素，可能会增加或减少风险以下childhood advertisement.AimsTo investigate major effects of，and synergistic between，childhood abuse and life events and cannabis use on odds of psychotic experiences.MethodData on psychotic experiences and childhood abuse，作为南东伦敦社区健康研究（SELCoH）的一部分，从1680个个体收集生活事件和大麻使用，一项以人口为基础的家庭调查。ResultsThere是强有力的证据表明，儿童期虐待和生活事件的数量相结合的协同作用，以增加超出每个单独的影响的精神病经验的几率。有类似的，但较弱的，大麻使用的证据（去年）。ConclusionsOur研究结果是一致的假设，即儿童虐待创建一个持久的脆弱性，精神病，是实现在事件中暴露于进一步的压力。和风险因素。
BackgroundThere is robust evidence that childhood adversity is associated with an increased risk of psychosis. There is, however, little research on intervening factors that might increase or decrease risk following childhood adversity.AimsTo investigate main effects of, and synergy between, childhood abuse and life events and cannabis use on odds of psychotic experiences.MethodData on psychotic experiences and childhood abuse, life events and cannabis use were collected from 1680 individuals as part of the South East London Community Health Study (SELCoH), a population-based household survey.ResultsThere was strong evidence that childhood abuse and number of life events combined synergistically to increase odds of psychotic experiences beyond the effects of each individually. There was similar, but weaker, evidence for cannabis use (past year).ConclusionsOur findings are consistent with the hypothesis that childhood abuse creates an enduring vulnerability to psychosis that is realised in the event of exposure to further stressors. and risk factors.