Persistence of muscle sympathetic nerve activity during vasovagal syncope
Persistence of muscle sympathetic nerve activity during vasovagal syncope
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DOI：
10.1093/eurheartj/ehq071
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发表时间：
2010-08-01
影响因子：
39.3
通讯作者：
Lambert, Elisabeth
中科院分区：
文献类型：
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作者：
Vaddadi, Gautam;Ester, Murray D.;Lambert, Elisabeth
目的是确定是否交感神经放电骨骼肌血管是撤回在血管迷走性晕厥（VVS）沉淀的被动分级头高位倾斜（HUT）table testing.Methods和results我们进行了被动分级HUT表测试18例患者的历史复发体位VVS，我们评估在晕厥事件。所有患者在测试期间均出现典型VVS。通过肱动脉内导管连续测量血压。使用腓神经中的电极测量肌肉交感神经活动（MSNA）。然后应用被动分级HUT。未使用药物引起晕厥。18例患者中有10例在晕厥事件中保持记录部位，我们能够证明9例患者在晕厥期间MSNA持续存在。该队列中晕厥的主要血流动力学模式为混合性低血压和心动过缓，心率不降
Aims To determine whether sympathetic nerve firing to skeletal muscle vasculature is withdrawn during vasovagal syncope (VVS) precipitated by passive graded head-up tilt (HUT) table testing.Methods and results We performed passive graded HUT table testing in 18 patients with a history of recurrent postural VVS whom we evaluated during the syncopal event. All patients developed typical VVS during testing. Blood pressure was measured continuously via intra-brachial arterial line. Muscle sympathetic nerve activity (MSNA) was measured using an electrode in the peroneal nerve. Passive graded HUT was then applied. No pharmacological agents were used to provoke syncope. The recording site was maintained through the syncopal event in 10 of 18 patients and we were able to demonstrate persistence of MSNA during syncope in 9. The predominant haemodynamic pattern of syncope in this cohort was mixed-hypotension and bradycardia, with heart rate not falling