Broad and fine-scale genetic analysis of white-tailed deer populations: estimating the relative risk of chronic wasting disease spread
Broad and fine-scale genetic analysis of white-tailed deer populations: estimating the relative risk of chronic wasting disease spread
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DOI：
10.1111/j.1752-4571.2010.00142.x
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发表时间：
2011-01-01
影响因子：
4.1
通讯作者：
Coltman, David W.
中科院分区：
文献类型：
--
作者：
Cullingham, Catherine I.;Merrill, Evelyn H.;Coltman, David W.
慢性消耗性疾病是一种可传播的鹿海绵状脑病，类似于最近才在加拿大西部野生白尾鹿(Odocoileus Virginianus)和骡鹿(Odocoileus Hemion Us Hemion Us)野生种群中发现的绵羊瘙痒病。人们对这种疾病的局部传播动态或远程传播的可能性知之甚少。我们使用微卫星图谱和线粒体DNA测序分析了来自艾伯塔省、不列颠哥伦比亚省和萨斯喀彻温省的2000多头白尾鹿的种群遗传结构，以评估疾病传播的相对风险。亚居群之间的分化很小，随着地理距离的增加，分化的趋势很弱。这表明，通过感染者的传播进行远距离疾病传播的可能性是可能的，但传播的风险应该随着距离感染源的距离而逐渐减小。在亚群中，女性在半径约500米范围内的亲缘关系超过预期(R>；0)。相关女性之间的性别偏见和社会互动可能会促进当地疾病在社会群体中的传播。因此，当在适当的空间尺度上实施时，地方羊群减少可能是降低疾病流行率的有效工具。
Chronic wasting disease is a transmissible spongiform encephalopathy of cervids, similar to sheep scrapie that has only recently been detected in wild populations of white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus hemionus) in western Canada. Relatively little is known about local transmission dynamics of the disease or the potential for long-distance spread. We analysed the population genetic structure of over 2000 white-tailed deer sampled from Alberta, British Columbia, and Saskatchewan using microsatellite profiles and mtDNA sequencing to assess the relative risk of disease spread. There was very little differentiation among subpopulations and a weak trend of increasing differentiation with geographic distance. This suggests that the potential for long-distance disease spread through the dispersal of infected individuals is possible, yet the risk of spread should gradually diminish with distance from infection foci. Within subpopulations, females were more related than expected by chance (R > 0) within a radius of approximately 500 m. Sex-biased philopatry and social interactions among related females may facilitate local disease transmission within social groups. Local herd reduction may therefore be an effective tool for reducing the disease prevalence when implemented at the appropriate spatial scale.