CRUCIFEROUS VEGETABLES AND GLUTATHIONE - THEIR EFFECTS ON COLON MUCOSAL GLUTATHIONE LEVEL AND COLON-TUMOR DEVELOPMENT IN RATS INDUCED BY DMH
CRUCIFEROUS VEGETABLES AND GLUTATHIONE - THEIR EFFECTS ON COLON MUCOSAL GLUTATHIONE LEVEL AND COLON-TUMOR DEVELOPMENT IN RATS INDUCED BY DMH
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DOI：
10.1080/01635589509514363
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发表时间：
1995-01-01
影响因子：
2.9
通讯作者：
BOYCE, HW
中科院分区：
文献类型：
--
作者：
CHEN, MF;CHEN, LT;BOYCE, HW
本文研究了以10-40%冻干甘蓝或花椰菜作为十字花科蔬菜或以10-40%冻干马铃薯作为非十字花科蔬菜饲喂14天对雄性大鼠结肠粘膜谷胱甘肽（GSH）水平的影响。同时测定十二指肠粘膜和肝脏的GSH含量。卷心菜和西兰花以剂量相关的方式增强结肠和十二指肠粘膜GSH水平;马铃薯没有影响。三种蔬菜对肝脏GSH含量均无影响，但GSH对二甲基肼（DMH）诱发的大鼠结肠癌的影响也进行了研究。雄性Sprague-Dawley大鼠每周注射DMH（20 mg/kg体重），持续20周。DMH降低结肠粘膜GSH水平。GSH（100毫克/天/大鼠）溶解在饮用水中，并在DMH注射期间和之后给予大鼠，对肿瘤发生率和结肠肿瘤总数几乎没有影响。接受GSH的大鼠的肿瘤比接受水的大鼠的肿瘤大。这项研究表明，结肠粘膜GSH水平可以提高喂养大鼠的饮食高白菜或西兰花和GSH添加到饮用水中没有影响DMH诱导的结肠肿瘤的实验条件下使用。
The effect of a diet containing 10-40% lyophilized cabbage or broccoli as cruciferous vegetable or 10-40% lyophilized potato as noncruciferous vegetable fed for 14 days on the colon mucosal glutathione (GSH) level was studied in male rats. The GSH levels of the duodenum mucosa and the liver were also measured. Cabbage and broccoli enhanced the colon and duodenum mucosal GSH level in a dose-related manner; potato had no effect. All three vegetables had no effect on the liver GSH level.The effect of GSH on colon tumorigenesis induced by 1,2-dimethylhydrazine (DMH) was also examined in rats. Male Sprague-Dawley rats were injected with DMH (20 mg/kg body wt) weekly for 20 weeks. DMH lowered the colon mucosal GSH level. GSH (100 mg/day/rat) dissolved in the drinking water and given to rats during and after DMH injections had little or no effect on tumor incidence and total number of colon tumors. Tumors were larger in rats that received GSH than in those that received water. This study shows that the colon mucosal GSH level can be enhanced by feeding rats a diet high in cabbage or broccoli and that GSH added to the drinking water did not affect DMH-induced colon tumorigenesis under the experimental conditions used.