Green tea consumption and risk of type 2 diabetes in Chinese adults: the Shanghai Women's Health Study and the Shanghai Men's Health Study
Green tea consumption and risk of type 2 diabetes in Chinese adults: the Shanghai Women's Health Study and the Shanghai Men's Health Study
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中国成年人绿茶摄入量与 2 型糖尿病风险：上海女性健康研究和上海男性健康研究
DOI：
10.1093/ije/dyy173
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发表时间：
2018-12-01
影响因子：
7.7
通讯作者：
Shu, Xiao-Ou
中科院分区：
文献类型：
--
作者：
Liu, Xiaona;Xu, Wanghong;Shu, Xiao-Ou
背景：饮茶与2型糖尿病（T2D）风险之间关系的流行病学证据并不一致。本研究前瞻性地调查了绿茶饮用是否会影响T2D的风险。方法：本研究纳入了来自上海女性健康研究（N = 67 058）和上海男性健康研究（N = 52 315）的无糖尿病受试者。在基线和后续调查中收集了茶叶消费的详细信息，包括种类和数量。事件T2D是通过后续调查确定的。在一项涉及592对糖尿病病例对照的巢式病例对照研究中，测量了血浆中咖啡因代谢物的水平。采用Cox回归分析，以饮茶作为时间相关变量，并通过倾向评分调整协变量，估计T2D风险的风险比（HR）和95%置信区间（CI）。采用Logistic回归分析评估咖啡因代谢物与T2D风险之间的关系。结果：与不经常饮用绿茶的人相比，经常饮用绿茶的人患T2D的风险增加[HR = 1.20 (95% Cl = 1.14-1.27)]。在饮茶时间和饮茶量之间观察到剂量-反应关系[P为趋势]
Background: Epidemiological evidence on the association between tea consumption and the risk of type 2 diabetes (T2D) is inconsistent. This study prospectively investigated whether green tea drinking affects the risk of T2D.Methods: This study included participants from the Shanghai Women's Health Study (N = 67 058) and the Shanghai Men's Health Study (N = 52 315) without diabetes at study enrolment. Details of tea consumption, including types and amounts, were collected at the baseline and follow-up survey. Incident T2D was identified through follow-up surveys. Plasma level of caffeine metabolite was measured in a nested case-control study involving 592 diabetes case-control pairs. Cox regression analysis, with tea drinking as a time-dependent variable and covariates adjusted for by a propensity score, was applied to estimate the hazard ratio (HR) and 95% confidence interval (CI) for T2D risk. Logistic regression analysis was applied to evaluate the association between caffeine metabolites and T2D risk.Results: Current green tea drinkers had an increased risk of T2D compared with non-current drinkers [HR = 1.20 (95% Cl = 1.14-1.27)]. and a dose-response relationship was observed for duration of drinking tea and the amount of tea consumed [P for trend