The Crucial Roles of Intermediate Metabolites in Cancer.
The Crucial Roles of Intermediate Metabolites in Cancer.
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中间代谢产物在癌症中的关键作用
DOI：
10.2147/cmar.s321433
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发表时间：
2021
影响因子：
3.3
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Huang S;Wang Z;Zhao L
代谢改变是肿瘤细胞的标志之一，对癌症的发生和发展具有重要意义。为了支持它们的快速生长，癌细胞改变了它们的新陈代谢，以获得必要的能量和生物合成途径的组成部分，并调节它们的氧化还原平衡。中间代谢物曾经被认为仅仅是代谢途径的副产物，现在人们知道它介导表观遗传修饰和蛋白质转录后修饰（PTM），并将细胞代谢与信号转导联系起来。因此，它们可以影响无数的过程，包括增殖、凋亡和免疫。本文综述了糖酵解、戊糖磷酸途径（PPP）、三羧酸（TCA）循环、脂质合成、酮生、蛋氨酸代谢、谷氨酰胺代谢和色氨酸代谢等具有代表性的代谢物，重点介绍了它们在染色质和蛋白质修饰以及作为信号转导信使中的作用。
Abstract Metabolic alteration, one of the hallmarks of cancer cells, is important for cancer initiation and development. To support their rapid growth, cancer cells alter their metabolism so as to obtain the necessary energy and building blocks for biosynthetic pathways, as well as to adjust their redox balance. Once thought to be merely byproducts of metabolic pathways, intermediate metabolites are now known to mediate epigenetic modifications and protein post-transcriptional modifications (PTM), as well as connect cellular metabolism with signal transduction. Consequently, they can affect a myriad of processes, including proliferation, apoptosis, and immunity. In this review, we summarize multiple representative metabolites involved in glycolysis, the pentose phosphate pathway (PPP), the tricarboxylic acid (TCA) cycle, lipid synthesis, ketogenesis, methionine metabolism, glutamine metabolism, and tryptophan metabolism, focusing on their roles in chromatin and protein modifications and as signal-transducing messengers.