A HOMOLOG OF THE ARMADILLO PROTEIN IN DROSOPHILA (PLAKOGLOBIN) ASSOCIATED WITH E-CADHERIN
A HOMOLOG OF THE ARMADILLO PROTEIN IN DROSOPHILA (PLAKOGLOBIN) ASSOCIATED WITH E-CADHERIN
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DOI：
10.1126/science.1962194
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发表时间：
1991-11-29
期刊：
影响因子：
56.9
通讯作者：
GUMBINER, B
中科院分区：
文献类型：
--
作者：
MCCREA, PD;TURCK, CW;GUMBINER, B
三种细胞质蛋白（称为连环蛋白）与上皮细胞间粘附分子 E-钙粘蛋白的细胞质尾部结合。确定了非洲爪蟾 92 千道尔顿 β-连环蛋白的互补 DNA 序列。该序列与哺乳动物斑珠蛋白（一种桥粒和小带粘附细胞连接处的蛋白质）同源，并且与果蝇中的斑珠蛋白同源物（节段极性基因犰狳的产物）同源。牛斑球蛋白的单克隆抗体可识别 Madin-Darby 犬肾 (MDCK) 细胞尖中的类似 β-连环蛋白。犰狳斑珠蛋白可能将 E-钙粘蛋白与细胞-细胞连接处的底层肌动蛋白细胞骨架连接起来； E-钙粘蛋白-连环蛋白复合物也可能参与发育信息的传递。
Three cytoplasmic proteins, called catenins, bind to the cytoplasmic tail of the epithelial cell-cell adhesion molecule E-cadherin. The complementary DNA sequence was determined for the 92-kilodalton beta-catenin of Xenopus laevis. The sequence is homologous to mammalian plakoglobin, a protein of desmosomal and zonula adherens cell junctions, and to the plakoglobin homolog in Drosophila melanogaster, the product of the segment polarity gene armadillo. A monoclonal antibody to bovine plakoglobin recognizes the analogous beta-catenin in the Madin-Darby canine kidney (MDCK) cell tine. Armadillo plakoglobin may link E-cadherin to the underlying actin cytoskeleton at cell-cell junctions; the E-cadherin-catenin protein complex may also participate in the transmission of developmental information.