Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean
Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean
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DOI：
10.1021/la101542m
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发表时间：
2010-07-06
期刊：
影响因子：
3.9
通讯作者：
Jiang, Shaoyi
中科院分区：
文献类型：
--
作者：
Cheng, Gang;Xue, Hong;Jiang, Shaoyi
提出了一种新的策略，整合抗菌和防污/生物相容性。将温和的抗微生物剂（水杨酸盐）掺入羧基甜菜碱酯水凝胶，聚（N，N-二甲基-N-（乙基羰基啉乙基）-N-[2-（甲基丙烯酰氧基）-乙基]水杨酸铵）（pCBMA-1 C2 SA）水凝胶中作为其阴离子抗衡物。这种新的水凝胶提供了抗微生物剂的持续释放，以抑制细菌的生长，并产生无污染的表面，以防止羧基甜菜碱酯水解成两性离子基团时蛋白质吸附或细菌积累。pCBMA-1 C2 SA水凝胶对革兰氏阴性大肠杆菌K12和革兰氏阳性表皮葡萄球菌的生长均抑制99.9%。这种水凝胶在伤口敷料和医疗器械表面涂层等应用中具有巨大的潜力。
A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylinethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to in the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.