Gender differences in the association of epicardial adipose tissue and coronary artery calcification: EPICHEART study EAT and coronary calcification by gender
Gender differences in the association of epicardial adipose tissue and coronary artery calcification: EPICHEART study EAT and coronary calcification by gender
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DOI：
10.1016/j.ijcard.2017.09.178
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发表时间：
2017-12-15
影响因子：
3.5
通讯作者：
Bettencourt, Nuno
中科院分区：
文献类型：
--
作者：
Mancio, Jennifer;Pinheiro, Marilia;Bettencourt, Nuno
背景：心外膜脂肪组织（EAT）和冠状动脉钙化（CAC）的关系似乎因性别而异。然而，很少有研究控制的身体大小，和身体大小indexing.Objectives的理想方法：分析性别相关的身体大小和体脂差异的影响EAT与CAC.Methods的关联：这是一个前瞻性队列的371例严重主动脉瓣狭窄患者（77 +/- 8.5岁，51%的女性）提到心脏手术。通过计算机断层扫描获得Agatston钙评分、EAT体积和内脏腹部脂肪（VAF）。使用生物电阻抗分析确定身体组成。测量体重和身高，以得出体重指数（BMI）、体表面积（BSA）和体表指数（BSI）。结果：男性CAC评分中位数（887; IQR：2010）高于女性（279：IQR：145）（p < 0.01）。同样，男性的EAT体积高于女性（137 +/- 65.6 vs. 106 +/- 65.6 mL，p < 0.01），即使是BSA或身高指数，但如果是体重指数，则不是。EAT体积与调整肥胖（BMI或BSI和VAF或脂肪量）的CAC相关，但与性别的进一步调整无关。在分层分析中，EAT的绝对和指数体积与男性CAC独立相关，而在女性中没有发现相关性（性别相互作用p < 0.05）。结论：在这些高危患者中，我们证明了EAT与男性CAC评分相关，而与男性的体型、体脂和心血管危险因素无关，但与女性无关。(C)2017 Elsevier B. V.版权所有。
Background: The association of epicardial adipose tissue (EAT) and coronary artery calcification (CAC) seems to differ by gender. However, few studies have controlled for body size, and the ideal method for body size indexing has not been explored.Objectives: To analyse the effect of gender related-body size and-body fat differences on the association of EAT with CAC.Methods: This was a prospective cohort of 371 severe aortic stenosis patients (77 +/- 8.5 year-old, 51% females) referred to cardiac surgery. Agatston calcium score, EAT volume and visceral abdominal fat (VAF) were obtained by computed tomography. Body composition was determined using bioelectrical impedance analysis. Body weight and height were measured to derive body mass index (BMI), body surface area (BSA), and body surface index (BSI). EAT volume was normalized for BSA, weight and height.Results: Median CAC score was higher in men (887; IQR: 2010) than in women (279: IQR: 145) (p < 0.01). Similarly, men had higher volume of EAT than women (137 +/- 65.6 vs. 106 +/- 65.6 mL, p < 0.01), even when BSA- or height-indexed, but not if weight-indexed. EAT volume was associated with CAC adjusting for adiposity (BMI or BSI and VAF, or fat mass), but not with further adjustment for gender. In a stratified analysis, absolute and indexed-volumes of EAT were independently associated with CAC in men while no association was found in women (gender-interaction p < 0.05).Conclusions: In these high-risk patients, we demonstrated that EAT was associated with CAC score irrespective of body size, body fat and cardiovascular risk factors in men but not in women. (C) 2017 Elsevier B.V. All rights reserved.