[Influence of menstrual and reproductive factors on the risk of lung cancer].
[Influence of menstrual and reproductive factors on the risk of lung cancer].
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DOI：
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发表时间：
2004-07
影响因子：
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通讯作者：
A. Brenner;Zuoyuan Wang;R. Kleinerman;Longde Wang;C. Metayer;J. Lubin
中科院分区：
文献类型：
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作者：
A. Brenner;Zuoyuan Wang;R. Kleinerman;Longde Wang;C. Metayer;J. Lubin
假设表明，当给予类似水平的烟草暴露时，女性患肺癌的风险高于男性，这意味着性相关激素可能起作用。这项研究旨在确定女性激素对肺癌风险的影响。方法1994 ~ 1998年在陇东地区进行了一项以人群为基础的病例对照研究，对一组自我反应的女性进行了月经/生殖因素与肺癌风险的相关性评价。该分析包括从人口普查名单中选择的109例肺癌病例和435例对照，并与年龄和地区相匹配。结果初潮年龄越大（趋势，P = 0.015）和绝经年龄越大（趋势，P = 0.074）的优势比越低。结论：尽管存在局限性，这些发现提示激素在女性肺癌病因中可能起作用。
OBJECTIVE Hypothesis showed that women have higher risks of lung cancer than men when given similar levels of tobacco exposure, implying that sex-related hormones might have a role to play. The study is to identify the influence of female hormones on risk of lung cancer. METHODS We evaluated the association between lung cancer risk and menstrual/reproductive factors on a subset of self-responding females in a population based case-control study in Eastern Gansu, 1994 - 1998. The analysis included 109 lung cancer cases and 435 controls selected from the census list and matched to cases on age and prefecture. RESULTS Odds ratios were lower for later ages at menarche (trend, P = 0.015) and later ages at menopause (trend, P = 0.074). CONCLUSION Despite limitations, these findings suggested a possible role related to hormones in the etiology of lung cancer in females.