Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer
Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer
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DOI：
10.1159/000015091
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Horii, A
中科院分区：
文献类型：
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作者：
Furukawa, T;Yatsuoka, T;Horii, A
DUSP6（别名 PYST1）是一种双特异性酪氨酸磷酸酶，定位于 12q21，这是胰腺癌中等位基因丢失频繁的区域之一。该基因由三个外显子组成，并且普遍表达两种形式的选择性剪接转录本。尽管在 26 个胰腺癌细胞系中未观察到突变，但在某些细胞系中观察到全长转录本表达减少，这可能表明 DUSP6 在胰腺癌发生中发挥一定作用。
DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.