Action-monitoring dysfunction in obsessive-compulsive disorder
Action-monitoring dysfunction in obsessive-compulsive disorder
复制标题
DOI：
10.1111/1467-9280.00206
复制
发表时间：
2000-01-01
影响因子：
8.2
通讯作者：
Nisenson, LG
中科院分区：
文献类型：
--
作者：
Gehring, WJ;Himle, J;Nisenson, LG
有证据表明，过度活跃的额-纹状体-丘脑-额神经回路与强迫症（OCD）的症状有关，但对这种过度活跃的功能却鲜有定论。我们报告的电生理学证据表明，该系统的一部分监测事件，并在事件与个人的内部标准或目标冲突时产生错误信号。9名强迫症患者和9名年龄、性别和教育程度相匹配的参与者执行了快速反应时间任务。与错误相关的消极情绪，一个反映行动监控过程的与事件相关的脑电位成分，在强迫症患者中得到增强。这种增强的程度与症状的严重程度相关。偶极子模型表明，增强的位置在内侧额叶区域，可能是前扣带皮层。
Evidence suggests that a hyperactive frontal-striatal-thalamix-frontal circuit is associated with the symptoms of obsessive-compulsive disorder (OCD), but there is little agreement about the function of the exaggerated activity. We report electrophysiological evidence suggesting that part of this system inonitors events and generates error signals when the events conflict with an individual's internal standards or goals. Nine individuals with OCD and 9 age-sex-, and education -matched participants performed a speeded reaction time task. The error-related negativity, an event-related brain potential component that reflects action-monitoring processes, was enhanced in the individuals with OCD. The magnitude of this enhancement correlated with symptom severity. Dipole modelling suggested that the locus of the enhancement to medial frontal regions, possibly the anterior cingulate cortex.