Cervimycin A-D:: A polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance
Cervimycin A-D:: A polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance
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DOI：
10.1002/chem.200500320
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发表时间：
2005-09-19
影响因子：
4.3
通讯作者：
Hertweck, C
中科院分区：
文献类型：
--
作者：
Herold, K;Gollmick, FA;Hertweck, C
Cervimycins A-D是一种新型的聚酮苷，对多重耐药葡萄球菌和万古霉素耐药肠球菌具有显著的活性。它们是由从一个古老的洞穴中分离出来的一种链霉菌产生的。通过进行广泛的NMR和化学降解研究确定了鹿鞭霉素的结构。所有的cervimycin都有一个共同的四环聚酮核心，被不寻常的二糖和四糖链取代，仅由三脱氧糖组成;然而，它们在乙酰基和氨基甲酰基环取代基以及非常不寻常的末端甲基丙二酰和二甲基丙二酰残基方面有所不同。
Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di-and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.