Specific IgE and IgG to gelatin in children with systemic cutaneous reactions to Japanese encephalitis vaccines
Specific IgE and IgG to gelatin in children with systemic cutaneous reactions to Japanese encephalitis vaccines
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DOI：
10.1034/j.1398-9995.2001.056006536.x
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发表时间：
2001-06-01
期刊：
影响因子：
12.4
通讯作者：
Inouye, S
中科院分区：
文献类型：
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作者：
Sakaguchi, M;Miyazawa, H;Inouye, S
背景：日本脑炎（JE）疫苗的全身过敏反应已有报道，包括荨麻疹、血管性水肿和皮疹。在日本，对乙型脑炎疫苗产生立即型过敏反应的儿童血清中含有抗明胶 IgE。然而，由乙脑疫苗接种后数小时或更长时间出现皮肤症状组成的非速发型过敏反应的免疫学机制尚未明确。方法：从对乙脑疫苗表现出非速发型皮肤过敏反应的28名儿童中采集血清样本。此外，还从 10 名儿童身上采集了血清样本，这些儿童对乙脑疫苗表现出立即型过敏反应，并伴有皮肤症状和/或呼吸道症状。我们将立即型反应定义为接种后1小时内发生的反应。结果：在出现立即型反应的10名儿童中，全部都有抗明胶IgE和IgG。在 28 名表现出全身性非立即型反应的儿童中，1 名出现抗明胶 IgE，9 名 (32%) 出现抗明胶 IgG。具有抗明胶IgE的儿童在接种乙脑后2小时出现荨麻疹。结论：这些结果表明，一些对乙脑疫苗表现出非立即型过敏反应的儿童对明胶过敏。
Background: Systemic allergic reactions to Japanese encephalitis (JE) vaccine that include urticaria, angioedema, and rash have been reported. In Japan, children who suffered from allergic immediate-type reactions to JE vaccine had antigelatin IgE in their sera. However, the immunologic mechanism of allergic nonimmediate-type reactions that consist of cutaneous signs appearing several hours or more after JE vaccination has not been defined.Methods: Serum samples were taken from 28 children who showed allergic nonimmediate-type cutaneous reactions to JE vaccine. Furthermore, serum samples were taken from 10 children who showed allergic immediate-type reactions with cutaneous signs and/or respiratory symptoms to JE vaccine. We have defined an immediate-type reaction as one occurring within 1 h after vaccination.Results: Of 10 children who showed immediate-type reactions, all had antigelatin IgE and IgG. Of 28 children who showed systemic nonimmediate-type reactions, one had antigelatin IgE and nine (32%) had antigelatin IgG. The child who had antigelatin IgE showed urticaria 2 h after JE vaccination.Conclusions: These results suggest that some children who showed allergic nonimmediate-type reactions to JE vaccine were sensitized to gelatin.