Variable speed of sound compensation in the linear-array photoacoustic tomography using a multi-stencils fast marching method
Variable speed of sound compensation in the linear-array photoacoustic tomography using a multi-stencils fast marching method
复制标题
使用多模板快速行进方法的线性阵列光声断层扫描中的可变速度声补偿
DOI：
10.1016/j.bspc.2018.04.012
复制
发表时间：
2018-07-01
影响因子：
5.1
通讯作者：
Feng, Naizhang
中科院分区：
文献类型：
--
作者：
Lin, Xiangwei;Sun, Mingjian;Feng, Naizhang
尽管线阵光声层析成像具有良好的临床应用前景，但已有研究表明，声速的变化会严重影响光声成像质量，导致传统的恒速假定延迟求和（DAS）重建中的目标退化和深度定位不准确。相比之下，多尺度快速推进（MSFM）方法能够对声速不均匀的组织产生精确的时间延迟图。该研究探索了DAS重建算法与MSFM方法的结合，以减少由于速度空间变化而导致的成像失真，其中目标结构和目标深度位置可以更精确地测量。为了验证所提出的方法的性能，数值，幻影，并在体内光声研究进行了定性和定量分析，特别是在检测小鼠脑深部肿瘤与完整的头骨。(C)2018爱思唯尔有限公司版权所有。
Despite the promising clinical application of linear-array photoacoustic tomography, it has been shown the variable speed of sound would severely affect the photoacoustic imaging quality, resulting in the target deterioration and inaccurate depth positioning in the conventional constant speed assumed delay and sum (DAS) reconstruction. By contrast, multi-stencils fast marching (MSFM) method is able to produce accurate time delay map for the tissue with inhomogeneous acoustic speed. This study explored the combination of DAS reconstruction algorithm with the MSFM approach to reduce the imaging distortions due to the speed spatial variation, where the target structure and target position in depth could be measured more precisely. To validate the performance of the proposed method, numerical, phantom, and in vivo photoacoustic studies were conducted with the qualitative and quantitative analysis, especially in the detection of mouse deep brain tumor with an intact skull. (C) 2018 Elsevier Ltd. All rights reserved.