Changes in the normal maximal expiratory flow-volume curve with growth and aging.
Changes in the normal maximal expiratory flow-volume curve with growth and aging.
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DOI：
10.1164/arrd.1983.127.6.725
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发表时间：
1983-06
期刊：
影响因子：
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通讯作者：
R. Knudson;M. Lebowitz;C. Holberg;B. Burrows
中科院分区：
文献类型：
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作者：
R. Knudson;M. Lebowitz;C. Holberg;B. Burrows
根据他们对自填问卷的回答，从代表亚利桑那州图森市非墨西哥裔美国白人群体的随机样本中选出了 697 名不吸烟的健康受试者，参加了一项呼吸系统健康纵向研究。对于每个受试者，选择在前 3 个连续调查期间获得的第一组令人满意的流量数据进行分析。对于用力肺活量 (FVC) 和一秒用力呼气量 (FEV1)，为每个受试者选择单一最佳值。其他流量测量值源自具有最佳总 FEV 和 FVC 的单次测试。这些数据用于推导按年龄组划分的每个性别的 5 个肺活量和流量变量的改进预测方程。由此产生的预测值证明了发育、成熟和衰老对通气功能的影响。提出的“正常”限制考虑了受试者之间的变异性和各种测量的非高斯分布。
On the basis of their answers to a self-administered questionnaire, 697 nonsmoking healthy subjects were chosen from a randomly selected sample representative of the white non-Mexican-American population of Tucson, Arizona, enrolled in a longitudinal study of respiratory health. For each subject, the first satisfactory set of flow-volume data obtained during the first 3 consecutive surveys was selected for analysis. For forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), the single best value for each subject was selected. Other flow-volume measurements were derived from the single test with the best sum FEV, plus FVC. These data were used to derive improved prediction equations for each sex by age group for 5 spirometric and flow-volume variables. The resulting predicted values demonstrate the effects of development, maturation, and senescence on ventilatory function. "Normal" limits are proposed that take into consideration the between-subject variability and non-Gaussian distribution of the various measurements.