Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases
Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases
复制标题
通过引入扭曲分子几何来放大激活的近红外余辉发光以了解中性粒细胞相关疾病
DOI：
10.1021/jacs.1c11455
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发表时间：
2022-01-20
影响因子：
15
通讯作者：
Ding, Dan
中科院分区：
文献类型：
--
作者：
Chen, Chao;Gao, Heqi;Ding, Dan
了解嗜中性粒细胞相关疾病的机制和进展（例如，急性炎症）非常重要。然而，现有的分析方法既不能实现实时监测，也不能提供病理过程中的动态信息。本文设计并合成了一种过氧亚硝酸根（OHOO-）和环境pH双重响应的余辉发光纳米探针。在生理pH下，ONOO-存在时，纳米探针显示出激活的近红外余辉发光，其强度和持续时间可以通过引入具有扭曲分子几何结构的聚集诱导发射（AIE）效应而大大增强。使用三种疾病动物模型的体内研究表明，纳米探针可以灵敏地揭示急性皮肤炎症的发展过程，包括首先到达的中性粒细胞的浸润和酸化起始时间，快速准确地区分过敏和炎症，并快速筛选能够诱导免疫原性细胞死亡的抗肿瘤药物。这项工作提供了一种替代方法和先进的探头，允许精确的疾病监测在真实的时间。
Understanding the mechanism and progression of neutrophil-involved diseases (e.g., acute inflammation) is of great importance. However, current available analytical methods neither achieve the real-time monitoring nor provide dynamic information during the pathological processes. Herein, a peroxynitrite (OHOO-) and environmental pH dual-responsive afterglow luminescent nanoprobe is designed and synthesized. In the presence of ONOO- at physiological pH, the nanoprobes show activated near-infrared afterglow luminescence, whose intensity and lasting time can be highly enhanced by introducing the aggregation-induced emission (AIE) effect with a twisted molecular geometry into the system. In vivo studies using three diseased animal models demonstrate that the nanoprobes can sensitively reveal the development process of acute skin inflammation including infiltration of first arrived neutrophils and acidification initiating time, make a fast and accurate discrimination between allergy and inflammation, and rapidly screen the antitumor drugs capable of inducing immunogenic cell death. This work provides an alternative approach and advanced probes permitting precise disease monitoring in real time.