Umbilical cord blood banking: an update
Umbilical cord blood banking: an update
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DOI：
10.1007/s10815-011-9577-x
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发表时间：
2011-08-01
影响因子：
3.1
通讯作者：
Menitove, Jay E.
中科院分区：
文献类型：
--
作者：
Butler, Merlin G.;Menitove, Jay E.
脐带血是原始造血干细胞和祖细胞的潜在巨大来源，可用于临床重建造血系统和/或恢复需要治疗的受影响个体的免疫功能。脐带血可以作为骨髓移植的替代来源，它的使用正在发展成为治疗患有血液病、免疫缺陷和特定遗传疾病的儿童和成人患者的新领域。自1988年首例脐带血移植以来，全球已进行了超过25,000例异体脐带血移植。储存脐带血有两种选择[私人（家庭）和公共]。储存在私人脐带血库的脐带血用于婴儿供体或相关家庭成员的自体或异体移植，但私人脐带血库无法搜索或向公众提供。全世界130多个私人脐带血银行储存着78万多份脐带血，100多个质量控制的公共脐带血银行储存着40多万份脐带血。研究人员继续评估脐带血细胞在血液系统疾病（包括心脏病、中风、脑或脊髓损伤和癌症）以外治疗人类疾病或障碍方面的有用性。本文综述了脐带血库的现状、历史、现状及在人类疾病治疗中的潜在应用。
Background Umbilical cord blood is a potential vast source of primitive hematopoietic stem and progenitor cells available for clinical application to reconstitute the hematopoietic system and/or restore immunological function in affected individuals requiring treatment. Cord blood can be used as an alternative source for bone marrow transplantation and its use is developing into a new field of treatment for pediatric and adult patients presenting with hematological disorders, immunological defects and specific genetic diseases.Discussion More than 25,000 allogeneic cord blood transplantations have been performed worldwide since the first cord blood transplantation in 1988. There are two banking options for storing umbilical cord blood [private (family) and public]. Cord blood stored in private banks are used for either autologous or allogeneic transplants for the infant donor or related family members but private cord blood banks are not searchable or available to the public. More than 780,000 cord blood units are stored in over 130 private cord blood banks, worldwide, and over 400,000 units in more than 100 quality controlled public cord blood banks.Conclusions Researchers continue to evaluate the usefulness of cord blood cells in treating human diseases or disorders for purposes other than hematological disorders including heart disease, strokes, brain or spinal cord injuries and cancer. This review summarizes the status of umbilical cord blood banking, its history and current and potential use in the treatment of human disease.