Nanoarchaeal Origin of Histone H3?

Nanoarchaeal Origin of Histone H3?
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DOI:
10.1128/jb.01431-08
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发表时间:
2009-02-01
影响因子:
3.2
通讯作者:
Huber, Harald
Huber, Harald
中科院分区:
生物学3区
文献类型:
--
作者:
Friedrich-Jahn, Ulrike;Aigner, Johanna;Huber, Harald

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NEQ288是马纳米古菌中的两种古菌组蛋白之一,具有独特的四个残基插入,非常类似于真核组蛋白H3谱系中的插入。NEQ 288在体外结合DNA,但在没有NEQ 348的情况下不压缩DNA,NEQ 348是第二个N.马古菌组蛋白。NEQ288的性质表明古菌和H3组蛋白谱系之间的中间体,以及真核组蛋白向现在强制性组装成异二聚体的进化步骤。
NEQ288, one of two archaeal histones in Nanoarchaeum equitans, has a unique four-residue insertion that closely resembles an insertion in the eukaryotic histone H3 lineage. NEQ288 bound DNA but did not compact DNA in vitro in the absence of NEQ348, the second N. equitans archaeal histone. The properties of NEQ288 suggest an intermediate between the archaeal and H3 histone lineages and an evolutionary step toward the now-mandatory assembly of eukaryotic histones into heterodimers.