Atypical teratoid/rhabdoid tumors
Atypical teratoid/rhabdoid tumors
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DOI：
10.1007/s00381-003-0731-3
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发表时间：
2003-04-01
影响因子：
1.4
通讯作者：
Ventureyra, ECG
中科院分区：
文献类型：
--
作者：
Dang, T;Vassilyadi, M;Ventureyra, ECG
病例报告：我们描述了三例非典型ATRT，确定在儿童医院东安大略。讨论：在过去的十年中，中枢神经系统的非典型畸胎样/横纹肌样肿瘤（ATRTs）已成为一个独特的实体。这种肿瘤通常被误诊为原始神经外胚层肿瘤（PNET）/髓母细胞瘤。ATRT独特的免疫组织化学特征有助于将其与PNET/髓母细胞瘤区分开来。这具有临床重要性，因为ATRT患者的预后比PNET/髓母细胞瘤更差，尽管加拿大积极的手术治疗有或没有辅助化疗和放疗。
Case reports: We describe three cases of atypical ATRT that were identified at the Children's Hospital of Eastern Ontario. Discussion: Over the past decade, atypical teratoid/rhabdoid tumors (ATRTs) of the central nervous system have emerged as a distinct entity. This tumor is typically misdiagnosed as a primitive neuroectodermal tumor (PNET)/medulloblastoma. The unique immunohistochemistry profile of an ATRT helps distinguish it from a PNET/medulloblastoma. This is of clinical importance because the prognosis of a patient with an ATRT is worse than that of a PNET/medulloblastoma despite Canada aggressive surgical treatment with or without adjuvant chemotherapy and radiation therapy.