Abnormal dynamic brain activity and functional connectivity of primary motor cortex in blepharospasm
Abnormal dynamic brain activity and functional connectivity of primary motor cortex in blepharospasm
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DOI：
10.1111/ene.15233
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发表时间：
2022-01-06
影响因子：
5.1
通讯作者：
Liu, Gang
中科院分区：
文献类型：
--
作者：
Luo, Yuhan;Guo, Yaomin;Liu, Gang
背景与目的近年来，低频波动的动态振幅（dALFF）或动态功能连接（dFC）在检测脑疾病的脑功能异常中，可以提供与低频波动的静态振幅（sALFF）或静态功能连接（sFC）不同的补充信息。我们的目的是检查dALFF和dFC是否可以提供有价值的信息检测眼睑痉挛患者的功能性脑异常。方法收集46例眼睑痉挛、面肌痉挛（HFS）和健康对照（HC）患者的静息态功能磁共振成像数据。我们检测了sALFF和dALFF的组间差异，以研究眼睑痉挛患者的异常局部脑活动。基于dALFF结果，我们进行了基于种子的sFC和dFC分析，以确定眼睑痉挛患者局部脑活动异常时间变异性区域为中心的脑网络中的静态和动态连接变化。结果眼睑痉挛患者与HCs患者相比，表现出不同的脑功能改变模式，主要表现为左侧初级运动皮层（PMC）sALFF增加，右侧PMC dALFF增加。然而，HFS和HC患者之间没有发现差异。此外，与HC相比，眼睑痉挛患者的右侧PMC和同侧小脑之间的dFC强度降低，但sFC无变化;将眼睑痉挛患者与HFS患者进行比较时，这些结果重复。结论dALFF和dFC与sALFF和sFC具有互补性，可为眼睑痉挛患者脑功能异常的检测提供有价值的信息。眼睑痉挛可能是一种涉及皮质-脑桥-小脑-丘脑-皮质回路的网络障碍。
Background and purpose Accumulating evidence indicates that dynamic amplitude of low-frequency fluctuations (dALFF) or dynamic functional connectivity (dFC) can provide complementary information, distinct from static amplitude of low-frequency fluctuations (sALFF) or static functional connectivity (sFC), in detecting brain functional abnormalities in brain diseases. We aimed to examine whether dALFF and dFC can offer valuable information for the detection of functional brain abnormalities in patients with blepharospasm. Methods We collected resting-state functional magnetic resonance imaging data from 46 patients each of blepharospasm, hemifacial spasm (HFS), and healthy controls (HCs). We examined intergroup differences in sALFF and dALFF to investigate abnormal regional brain activity in patients with blepharospasm. Based on the dALFF results, we conducted seed-based sFC and dFC analyses to identify static and dynamic connectivity changes in brain networks centered on areas showing abnormal temporal variability of local brain activity in patients with blepharospasm. Results Compared with HCs, patients with blepharospasm displayed different brain functional change patterns characterized by increased sALFF in the left primary motor cortex (PMC) but increased dALFF variance in the right PMC. However, differences were not found between patients with HFS and HCs. Additionally, patients with blepharospasm exhibited decreased dFC strength, but no change in sFC, between right PMC and ipsilateral cerebellum compared with HCs; these findings were replicated when patients with blepharospasm were compared to those with HFS. Conclusions Our findings highlight that dALFF and dFC are complementary to sALFF and sFC and can provide valuable information for detecting brain functional abnormalities in blepharospasm. Blepharospasm may be a network disorder involving the cortico-ponto-cerebello-thalamo-cortical circuit.