Incremental changes in interhemispheric functional connectivity after two-stage corpus callosotomy in a patient with subcortical band heterotopia.
Incremental changes in interhemispheric functional connectivity after two-stage corpus callosotomy in a patient with subcortical band heterotopia.
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DOI：
10.1016/j.ebr.2022.100525
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发表时间：
2022
影响因子：
--
通讯作者：
Kumada S
中科院分区：
文献类型：
--
作者：
Matsuhashi A;Matsuo T;Kumada S
从头皮EEG计算的相干性可用于评估功能连接性。前/后胼胝体切开术后，功能连接逐步下降。功能连接与发作频率变化相关。功能连接可能反映胼胝体切开术的癫痫发作结果。据报道，胼胝体切开术（CC）可有效减少耐药性癫痫患者的全身性癫痫发作。然而，疗效仅通过癫痫发作频率来衡量，没有任何电生理学指导。在此，我们进行了定量分析的大脑半球间的功能连接使用头皮脑电图（EEG）的电极间的一致性在临床病例的皮层下带状异位，以评估其与癫痫发作频率的关系。在我们的病例中，癫痫发作频率在后CC后显著降低，但在前CC后没有。后CC后电极间相干性也降低，表明其与癫痫发作频率相关。本病例研究支持使用电极间相干性作为电生理工具，可作为评估CC有效性的预测因素。
Coherence calculated from scalp EEG may be utilized to evaluate functional connectivity. Functional connectivity decreased stepwise after anterior/posterior callosotomy. Correlation was seen between functional connectivity and seizure frequency change. Functional connectivity may reflect seizure outcome of callosotomy. Corpus callosotomy (CC) has been reported to be effective in reducing generalized seizures in patients with drug-resistant epilepsies. However, efficacy is measured only by seizure frequency, without any electrophysiological guidance. Herein, we conducted a quantitative analysis of interhemispheric functional connectivity using inter-electrode coherence of scalp electroencephalogram (EEG) in a clinical case of subcortical band heterotopia to evaluate its relationship with seizure frequency. In our case, seizure frequency decreased significantly after posterior CC but not after anterior CC. Inter-electrode coherence also decreased after posterior CC, suggesting it correlated with seizure frequency. This case study supports the use of inter-electrode coherence as an electrophysiological tool that is useful as predictive factor in evaluating the effectiveness of CC.
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影响因子：
4.7
作者：
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