Ventral striatum encodes past and predicted value independent of motor contingencies.
Ventral striatum encodes past and predicted value independent of motor contingencies.
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DOI：
10.1523/jneurosci.5349-11.2012
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发表时间：
2012-02-08
期刊：
影响因子：
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通讯作者：
Roesch MR
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文献类型：
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作者：
Goldstein BL;Barnett BR;Vasquez G;Tobia SC;Kashtelyan V;Burton AC;Bryden DW;Roesch MR
腹侧纹状体（VS）被认为是预期结果的预测值的信号。然而，目前还不清楚VS是否可以独立于经常与值相关联的变量（如响应方向和延迟）来编码值。对高价值回报的期望通常与特定的行动和更快的睡眠有关。为了解决这个问题，我们训练大鼠执行一项任务，在该任务中，在指示仪器反应之前，预测奖励的大小被发出信号。仪器方向线索简要地提出了一个变量的开始，以减少准确性和增加反应时间。当奖励大小不一的时候，老鼠更准确，也更慢。我们发现，在VS的活动是高的气味，预测大的奖励，即使在这些条件下的反应时间较慢。除了这些影响，我们发现，奖励预测线索之前的活动反映了过去和预测的奖励。这些结果表明，VS可以独立于运动意外事件编码价值，并且VS在目标导向行为中的作用不仅仅是在更多的情况下增加特定动作的活力。
The ventral striatum (VS) is thought to signal the predicted value of expected outcomes. However, it is still unclear whether VS can encode value independently from variables often yoked to value such as response direction and latency. Expectations of high value reward are often associated with a particular action and faster latencies. To address this issue we trained rats to perform a task in which the size of the predicted reward was signaled before the instrumental response was instructed. Instrumental directional cues were presented briefly at a variable onset to reduce accuracy and increase reaction time. Rats were more accurate and slower when a large versus small reward was at stake. We found that activity in VS was high during odors that predicted large reward even though reaction times were slower under these conditions. In addition to these effects, we found that activity prior to the reward predicting cue reflected past and predicted reward. These results demonstrate that VS can encode value independent of motor contingencies and that VS’s role in goal-directed behavior is not just to increase vigor of specific actions when more is at stake.