The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis
The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis
复制标题
血管紧张素转换酶基因I/D多态性与哮喘风险的荟萃分析
DOI：
10.1111/j.1398-9995.2010.02438.x
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发表时间：
2011-02-01
期刊：
影响因子：
12.4
通讯作者：
Fan, H.
中科院分区：
文献类型：
--
作者：
Zhang, Y. -G.;Li, X. -B.;Fan, H.
背景：血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与哮喘易感性有关，但大量研究报道结果不明确。方法：计算机检索Medline(Ovid)、Pubmed、CNKI、万方、微普等数据库，检索至2010年3月12日。使用Revman4.2(The Cochrane Collaboration，http://www.cochrane.org)http://www.stata.com).Results:A Stata 10.0(StataCorp，College Station，USA，TX，USA)软件进行统计分析，共纳入18项病例对照研究中的1,946例和2,152例对照。结果表明，与纯合子II和杂合子DI相比，DD纯合子携带者患哮喘的风险增加59%[优势比(OR)=1.59，95%可信区间(CI)：1.16~2.18]。在按种族划分的亚组分析中，亚洲人DD纯合子携带者的风险显著增加(DD与DI+II的OR分别为2.02和95%CI：1.29-3.16)，而高加索人则不相关(DD与DI+II的OR分别为1.14和95%CI：0.76-1.72)。在按年龄分组分析中，儿童DD纯合子携带者的风险显著增加(DD vs II+DI的OR=2.44和95%CI：1.36~4.38)，而成人则不显著(DD vs II+DI的OR=1.54和95%CI：0.94~2.51)。结论：该Meta分析提示ACE基因I/D多态性可能是哮喘的危险因素。为了进一步评估ACE基因多态与哮喘风险之间的基因到基因和基因到环境的交互作用，还需要更多的大组患者研究。
P>Background:The insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study is to investigate the association between the I/D polymorphism of ACE gene and asthma risk by meta-analysis.Methods:We searched Medline (Ovid), Pubmed, CNKI, Wanfang, and Weipu database, covering all papers until March 12, 2010. Statistical analysis was performed by using the software revman 4.2 (The Cochrane Collaboration, http://www.cochrane.org) and stata 10.0 (StataCorp, College Station, TX, USA, http://www.stata.com).Results:A total of 1946 cases and 2152 controls in 18 case-control studies were included in this meta-analysis. The results indicated that the DD homozygote carriers had a 59% increased risk of asthma, when compared with the homozygotes II and heterozygote DI [odds ratio (OR) = 1.59, 95% confidence interval (CI): 1.16-2.18]. In the subgroup analysis by ethnicity, significant elevated risks were associated with DD homozygote carriers in Asians (OR = 2.02 and 95% CI: 1.29-3.16 for DD vs DI+II) but not in Caucasians (OR = 1.14 and 95% CI: 0.76-1.72 for DD vs DI+II). In the subgroup analysis by age, significant elevated risks were associated with DD homozygote carriers in children (OR = 2.44 and 95% CI: 1.36-4.38 for DD vs II+DI) but not in adults (OR = 1.54 and 95% CI: 0.94-2.51 for DD vs II+DI).Conclusions:This meta-analysis suggested that the I/D polymorphism of ACE gene would be a risk factor of asthma. To further evaluate gene-to-gene and gene-to-environment interactions between polymorphisms of ACE gene and asthma risk, more studies with large groups of patients are required.