Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry
Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry
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DOI：
10.1172/jci13799
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发表时间：
2001-08-01
影响因子：
15.9
通讯作者：
Spear, PG
中科院分区：
文献类型：
--
作者：
Shukla, D;Spear, PG
细胞表面蛋白聚糖上的糖胺聚糖链为各种病毒和其他微生物与真核细胞的结合提供初始对接位点。普遍表达的硫酸糖胺聚糖在这方面特别重要，至少对于病毒来说是这样。通常，病毒蛋白与硫酸乙酰肝素的结合只是病毒和细胞之间相互作用级联的第一步，这是病毒进入细胞并引发感染所必需的。病毒与硫酸乙酰肝素结合后发生的步骤可能需要其他病毒蛋白与其他细胞表面分子的相互作用。本观点的重点是几种人类疱疹病毒，它们可以通过与细胞表面硫酸乙酰肝素结合来与细胞进行初步接触。该组的一个成员，单纯疱疹病毒1型（HSV-1），也可以结合到硫酸乙酰肝素中的特定位点，以触发病毒进入所需的病毒包膜和细胞膜之间的融合。
Glycosaminoglycan chains on cell surface proteoglycans provide initial docking sites for the binding to eukaryotic cells of various viruses and other microorganisms. The ubiquitously expressed glycosaminoglycan heparan sulfate is particularly important in this regard, at least for viruses. Often, binding of a viral protein to heparan sulfate is only the first step in a cascade of interactions between virus and cell that is required for viral entry into the cell and the initiation of infection. The steps that occur after binding of virus to heparan sulfate may require the interaction of other viral proteins with other cell surface molecules.Several of the human herpesviruses, the focus of this Perspective, can make their initial contact with cells by binding to cell surface heparan sulfate. One member of this group, herpes simplex virus type 1 (HSV-1), can also bind to specific sites in heparan sulfate to trigger the fusion between viral envelope and cell membrane that is required for viral entry.