Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2.
Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2.
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DOI：
10.3340/jkns.2017.0295
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发表时间：
2018-11
影响因子：
1.6
通讯作者：
Choe S
中科院分区：
文献类型：
--
作者：
Ryu D;Yoon BH;Oh CH;Kim MH;Kim JY;Yoon SH;Choe S
采用大鼠脊柱后外侧融合模型，比较激活素A/BMP2嵌合体(AB204)与重组人骨形态发生蛋白(RhBMP2)的脊柱融合特性。本研究旨在比较不同剂量的AB204和rhBMP2在脊柱融合中的效果和性能。在研究期间，6 1只雄性SD大鼠接受了9种治疗方法之一的腰椎后外侧融合术，即假手术组；单纯骨组；重组人骨形成蛋白2与骨组的3.0μg、6.0μg或10.0μg组；AB2 0 4组与骨组的1.0μg、3.0μg、6.0μg或10.0μg组。分别于治疗后4周和8周通过物理触诊、X线平片、显微计算机断层扫描和免疫组织化学评分，计算其对脊柱骨融合的影响和性质。10.0μg AB204和10.0μg重组人骨形态发生蛋白2组的骨融合评分显著高于单纯骨组和1.0μg AB204组。AB204具有比rhBMP2更长的成骨活性。6.0和10.0μg时，AB2 0 4的骨融合性能与rh BMP2相似，但3.0μg时，AB2 0 4的骨融合性能优于3.0μg时，AB2 0 4嵌合体可能比rh BMP2更有效地治疗脊柱融合，并具有更长的成骨活性。
To compare the spinal bone fusion properties of activin A/BMP2 chimera (AB204) with recombinant human bone morphogenetic protein (rhBMP2) using a rat posterolateral spinal fusion model. The study was designed to compare the effects and property at different dosages of AB204 and rhBMP2 on spinal bone fusion. Sixty-one male Sprague-Dawley rats underwent posterolateral lumbar spinal fusion using one of nine treatments during the study, that is, sham; osteon only; 3.0 μg, 6.0 μg, or 10.0 μg of rhBMP2 with osteon; and 1.0 μg, 3.0 μg, 6.0 μg, or 10.0 μg of AB204 with osteon. The effects and property on spinal bone fusion was calculated at 4 and 8 weeks after treatment using the scores of physical palpation, simple radiograph, micro-computed tomography, and immunohistochemistry. Bone fusion scores were significantly higher for 10.0 μg AB204 and 10.0 μg rhBMP2 than for osteon only or 1.0 μg AB204. AB204 exhibited more prolonged osteoblastic activity than rhBMP2. Bone fusion properties of AB204 were similar with the properties of rhBMP2 at doses of 6.0 and 10.0 μg, but, the properties of AB204 at doses of 3.0 μg exhibited better than the properties of rhBMP2 at doses of 3.0 μg. AB204 chimeras could to be more potent for treating spinal bone fusion than rhBMP2 substitutes with increased osteoblastic activity for over a longer period.
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影响因子：
5.3
作者：
KOENIG, BB;COOK, JS;ROSENBAUM, JS
通讯作者：
ROSENBAUM, JS
DOI：
10.1073/pnas.0602558103
发表时间：
2006-05-16
影响因子：
11.1
作者：
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作者：
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作者：
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通讯作者：
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影响因子：
3
作者：
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通讯作者：
Rampersaud, Yoga Raja