Effect of glucocorticoids on renal net glucose release in vivo in normal and diabetic rats.
Effect of glucocorticoids on renal net glucose release in vivo in normal and diabetic rats.
复制标题
糖皮质激素对正常和糖尿病大鼠体内肾净葡萄糖释放的影响。
DOI：
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发表时间：
1983
影响因子：
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通讯作者：
H. Nakagawa
中科院分区：
文献类型：
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作者：
F. Kamiya;H. Kimura;T. Takeuchi;K. Kida;H. Nakagawa
用同位素稀释法研究了糖皮质激素对正常和糖尿病大鼠肾脏葡萄糖净释放的影响。对正常进食大鼠给予氢化可的松使肾脏净葡萄糖释放从0.93 +/- 0.25 mg增加至2.27 +/- 0.21 mg。dl-1。min-1，并将其对血糖的贡献从27.0 +/-4.5%增加到46.6 +/-4.0%。肾上腺切除大鼠的肾脏净葡萄糖释放及其对血糖的贡献为0.40 ± 0.06 mg。dl-1。min-1和16.3 ± 1.4%，显著低于正常对照组大鼠，而这些参数通过给予氢化可的松升高至正常对照组大鼠的水平。在链脲佐菌素诱导的糖尿病大鼠中，肾脏净葡萄糖释放及其对血糖的贡献显著增加至2.22 +/- 0.51 mg。dl-1。min-1和46.7 +/-4.9%，这些参数通过肾上腺切除术恢复正常。这些数据表明，糖皮质激素在调节正常和糖尿病大鼠肾脏净葡萄糖释放及其对血糖的贡献中起重要作用。
The effect of glucocorticoids on renal net glucose release in vivo in normal and diabetic rats was studied by the isotope-dilution method. Administration of hydrocortisone to normal fed rats increased renal net glucose release from 0.93 +/- 0.25 to 2.27 +/- 0.21 mg . dl-1 . min-1 and increased its contribution to blood glucose from 27.0 +/- 4.5 to 46.6 +/- 4.0%. The renal net glucose release and its contribution to blood glucose in adrenalectomized rats were 0.40 +/- 0.06 mg . dl-1 . min-1 and 16.3 +/- 1.4%, respectively, significantly less than those of normal control rats, and these parameters were raised to the levels of normal control rats by the administration of hydrocortisone. In rats with streptozotocin-induced diabetes, the renal net glucose release and its contribution to blood glucose were significantly increased to 2.22 +/- 0.51 mg . dl-1 . min-1 and 46.7 +/- 4.9%, respectively, and these parameters were normalized by adrenalectomy. These data indicate that glucocorticoids play an important role in regulation of renal net glucose release and its contribution to blood glucose in both normal and diabetic rats.