Asymmetric N-Heterocyclic Carbene (NHC) Catalyzed Acyl Anion Reactivity.
Asymmetric N-Heterocyclic Carbene (NHC) Catalyzed Acyl Anion Reactivity.
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作者：
H. Vora;T. Rovis
自 20 世纪 60 年代初以来，合成界一直对酰基阴离子等价物的产生感兴趣。在可用于生成酰基阴离子（或酰基阴离子等价物）的众多方法中，醛基阴离子的催化生产是通过使用氰化物和 N-杂环卡宾 (NHC) 进行的。后者已成为在反极性过程中催化醛形成酰基阴离子等价物的重要方法，促进新转化的发现和不对称变体的开发。这一快速发展的有机催化领域 1 已成为许多综述的主题，这些综述详细介绍了该领域众多研究人员的贡献。2 本综述将讨论 NHC 在酰基阴离子等价物的生成及其在合成中的应用的出现和发展。
The generation of acyl anion equivalents has been of interest to the synthetic community since the early 1960’s. Of the numerous methods available to generate acyl anions (or acyl anion equivalents), their catalytic production from aldehydes has been through the use of cyanide and N-heterocyclic carbenes (NHCs). The latter has emerged as a prominent method to catalyze the formation of acyl anion equivalents from aldehydes in an umpolung process facilitating the discovery of new transformations and the development of asymmetric variants. This rapidly growing field of organocatalysis1 has been the subject of many reviews which detail the contributions from numerous researchers in this area.2 The present review will discuss the advent and development of NHCs in the generation of acyl anion equivalents and their use in synthesis.