EFFECTS OF SUPPLEMENTATION WITH HIGH-SELENIUM WHEAT BREAD ON SELENIUM, GLUTATHIONE-PEROXIDASE AND RELATED ENZYMES IN BLOOD COMPONENTS OF NEW-ZEALAND RESIDENTS
EFFECTS OF SUPPLEMENTATION WITH HIGH-SELENIUM WHEAT BREAD ON SELENIUM, GLUTATHIONE-PEROXIDASE AND RELATED ENZYMES IN BLOOD COMPONENTS OF NEW-ZEALAND RESIDENTS
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DOI：
10.1093/ajcn/41.5.1015
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发表时间：
1985-01-01
影响因子：
7.1
通讯作者：
ROBINSON, MF
中科院分区：
文献类型：
--
作者：
THOMSON, CD;ONG, LK;ROBINSON, MF
研究1.11.1.9富硒小麦面包对硒含量、谷胱甘肽过氧化物酶（GSHPx）活性及相关酶活性的影响。四名新西兰妇女每天补充200 μ g Se，持续8-13周，随后是9-12周的给药后时期。全血、红细胞、血浆和血小板中GSH Px活性均升高，但升高幅度明显小于全血、血浆和红细胞中Se浓度的升高幅度。在给药后期间，硒浓度和GSHPx活性下降到在大多数情况下略高于基线值的水平。红细胞、血浆和血小板中的谷胱甘肽-S-转移酶活性在研究期间没有变化，红细胞和血小板中的超氧化物歧化酶、红细胞过氧化氢酶或血浆α-谷胱甘肽-S-转移酶也没有变化。生育酚。因此，硒补充健康的新西兰受试者增加GSHPx活性，但没有产生任何适应性变化的其他组成部分的脂质过氧化防御机制。
The effects of supplementation with high-Se wheat bread on Se concentrations, glutathione peroxidase (EC 1.11.1.9, GSHPx) activities and related enzymes in the prevention of lipid peroxidation were studied. Four New Zealand women were supplemented with 200 .mu.g Se daily for 8-13 wk followed by a post-dosing period of 9-12 wk. GSHPx activities increased in whole blood, erythrocytes, plasma and platelets of all subjects but increases were considerably less than those of Se concentrations in whole blood, plasma and erythrocytes. During the post-dosing period Se concentrations and GSHPx activities fell to levels which were in most cases somewhat higher than baseline values. Glutathione-S-transferase activities in erythrocytes, plasma and platelets did not change during the study, nor did superoxide dismutase in erythrocytes and platelets, erythrocytes catalase or plasma .alpha.-tocopherol. Thus, Se supplementation of healthy New Zealand subjects increased GSHPx activities but did not produce any adaptive changes in other components of the lipid peroxidation defense mechanisms.