Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study
Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study
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DOI：
10.1016/j.ajo.2015.04.007
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发表时间：
2015-07-01
影响因子：
4.2
通讯作者：
Medeiros, Felipe A.
中科院分区：
文献类型：
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作者：
Abe, Ricardo Y.;Gracitelli, Carolina P. B.;Medeiros, Felipe A.
目得：评估倍频技术（FDT）视野检查的变化率与青光眼患者生活质量（QoL）纵向变化之间的关系。设计：前瞻性观察队列研究。方法：152例受试者（127例青光眼和25例健康人）平均随访3.2 +/- 1.1年。所有受试者均接受国家眼科研究所视觉功能问卷（NET VFQ-25）、FDT和标准自动视野检查（SAP）进行评估。青光眼患者在随访期间平均有3次NET VFQ-25、8次FDT和8次SAP测试。估计FDT和SAP的综合双眼视野的平均灵敏度，并用于计算变化率。联合纵向多变量混合模型被用来调查双眼平均敏感性的变化和NET VFQ-25 Rasch校准scores.Results的变化之间的关联：有一个统计学显着的相关性之间的变化，双眼平均敏感性FDT和变化NET VFQ-25分数在青光眼组的后续。在混杂因素的多变量分析中，双眼FDT平均灵敏度每变化1 dB/年对应于NET VFQ-25评分每年变化0.8个单位（P =.001）。对于双眼SAP平均灵敏度，每1dB/年的变化与NET VFQ-25评分每年2.4个单位的变化相关（P < .001）。与EDT的等效模型相比，包含SAP基线和变化率信息的多变量模型预测NET VFQ-25评分变化的能力更强（R-2分别为50%和30%; P = 0.001）。SAP在预测我们人群的NET VFQ-25评分变化方面明显优于EDT，这表明它可能仍然是预测该疾病致残风险的首选外周检查技术。(C)2015年，Elsevier Inc. All rights reserved.
PURPOSE: To evaluate the relationship between rates of change on frequency doubling technology (FDT) perimetry and longitudinal changes in quality of life (QoL) of glaucoma patients.DESIGN: Prospective observational cohort study.METHODS: One hundred fifty-two subjects (127 glaucoma and 25 healthy) were followed for an average of 3.2 +/- 1.1 years. All subjects were evaluated with National Eye Institute Visual Function Questionnaire (NET VFQ-25), FDT, and standard automated perimetry (SAP). Glaucoma patients had a median of 3 NET VFQ-25, 8 FDT, and 8 SAP tests during follow-up. Mean sensitivities of the integrated binocular visual fields were estimated for FDT and SAP and used to calculate rates of change. A joint longitudinal multivariable mixed model was used to investigate the association between change in binocular mean sensitivities and change in NET VFQ-25 Rasch-calibrated scores.RESULTS: There was a statistically significant correlation between change in binocular mean sensitivity for FDT and change in NET VFQ-25 scores during follow-up in the glaucoma group. In multivariable analysis with the confounding factors, each 1 dB/year change in binocular FDT mean sensitivity corresponded to a change of 0.8 units per year in the NET VFQ-25 scores (P =.001). For binocular SAP mean sensitivity, each 1 dB/year change was associated with 2.4 units per year change in NET VFQ-25 scores (P < .001). The multivariable model containing baseline and rate of change information from SAP had stronger ability to predict change in NET VFQ-25 scores compared to the equivalent model for EDT (R-2 of 50% and 30%, respectively; P =.001).CONCLUSION: SAP performed significantly better than EDT in predicting change in NET VFQ-25 scores in our population, suggesting that it may still be the preferable perimetric technique for predicting risk of disability from the disease. (C) 2015 by Elsevier Inc. All rights reserved.