Disrupted functional brain network organization in patients with obstructive sleep apnea.
Disrupted functional brain network organization in patients with obstructive sleep apnea.
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DOI：
10.1002/brb3.441
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发表时间：
2016-03
影响因子：
3.1
通讯作者：
Kumar R
中科院分区：
文献类型：
--
作者：
Park B;Palomares JA;Woo MA;Kang DW;Macey PM;Yan-Go FL;Harper RM;Kumar R
阻塞性睡眠呼吸暂停（OSA）受试者表现出自主、情感、执行、感觉运动和认知功能受损。OSA受试者的脑损伤出现在多个调节这些功能的位点，但调节位点内功能网络的完整性尚不清楚。我们的目的是利用区域功能连接（FC）和脑网络拓扑特性，研究OSA患者全脑的功能相互作用和这些相互作用的复杂网络组织。我们使用3.0 - Tesla MRI扫描仪收集了69名新诊断、治疗naïve、中重度OSA（年龄48.3±9.2岁；体重指数31±6.2 kg/m2；呼吸暂停低通气指数（AHI） 35.6±23.3事件/h）和82名对照受试者（47.6±9.1岁；体重指数25.1±3.5 kg/m2）的静息状态功能磁共振成像（MRI）数据。分析数据以检查OSA患者的FC与对照组的区域间相关性和脑网络拓扑特性。阻塞性睡眠呼吸暂停患者在小脑、额叶、顶叶、颞叶、枕叶、边缘和基底节区的FC显著改变（FDR, P < 0.05）。OSA受试者的整个脑功能网络整合效率明显降低，其功能整合和专业化特征的区域拓扑特性在FC改变区域也呈现下降趋势，这将干扰脑网络组织（P < 0.05; 10,000个排列）。OSA患者拓扑结构异常的脑部位与AHI评分有显著相关性。我们的研究结果表明，这种功能障碍延伸到静息状态，FC的改变和网络组织的受损可能是自主神经、认知和感觉运动功能受损的基础。这种结果可能是由于轴突和核结构在这种情况下发生了显著的结构变化。
Obstructive sleep apnea (OSA) subjects show impaired autonomic, affective, executive, sensorimotor, and cognitive functions. Brain injury in OSA subjects appears in multiple sites regulating these functions, but the integrity of functional networks within the regulatory sites remains unclear. Our aim was to examine the functional interactions and the complex network organization of these interactions across the whole brain in OSA, using regional functional connectivity (FC) and brain network topological properties. We collected resting‐state functional magnetic resonance imaging (MRI) data, using a 3.0‐Tesla MRI scanner, from 69 newly diagnosed, treatment‐naïve, moderate‐to‐severe OSA (age, 48.3 ± 9.2 years; body mass index, 31 ± 6.2 kg/m2; apnea–hypopnea index (AHI), 35.6 ± 23.3 events/h) and 82 control subjects (47.6 ± 9.1 years; body mass index, 25.1 ± 3.5 kg/m2). Data were analyzed to examine FC in OSA over controls as interregional correlations and brain network topological properties. Obstructive sleep apnea subjects showed significantly altered FC in the cerebellar, frontal, parietal, temporal, occipital, limbic, and basal ganglia regions (FDR, P < 0.05). Entire functional brain networks in OSA subjects showed significantly less efficient integration, and their regional topological properties of functional integration and specialization characteristics also showed declined trends in areas showing altered FC, an outcome which would interfere with brain network organization (P < 0.05; 10,000 permutations). Brain sites with abnormal topological properties in OSA showed significant relationships with AHI scores. Our findings suggest that the dysfunction extends to resting conditions, and the altered FC and impaired network organization may underlie the impaired responses in autonomic, cognitive, and sensorimotor functions. The outcomes likely result from the prominent structural changes in both axons and nuclear structures, which occur in the condition.