Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth
Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth
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DOI：
10.1016/j.bbrc.2007.12.091
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发表时间：
2008-03-07
影响因子：
3.1
通讯作者：
Ishizaka, Shigeaki
中科院分区：
文献类型：
--
作者：
Ouji, Yukiteru;Yoshikawa, Masahide;Ishizaka, Shigeaki
尽管Wnt在从胚胎到成年的整个生命过程中都在毛囊中表达，并且被认为对其发育和成熟至关重要，但它们的作用在很大程度上仍然未知。在本研究中，我们研究了Wnt（Wnt-3a，Wnt-5a，Wnt-10 b和Wnt-11）对上皮细胞分化的影响，使用成年小鼠来源的原代皮肤上皮细胞（MPSEC）培养和毛发生长，使用毛囊器官培养。与Wnt-3a、5a和11相反，只有Wnt-10 b显示出明显的促进上皮细胞分化和毛干生长。我们的研究结果表明，Wnt-10 b是独特的，在毛囊上皮细胞的分化中起着重要作用。(c)2007爱思唯尔公司All rights reserved.
Although Wnts are expressed in hair follicles throughout life from embryo to adult, and considered to be critical for their development and maturation, their roles remain largely unknown. In the present study, we investigated the effects of Wnts(Wnt-3a, Wnt-5a, Wnt-10b, and Wnt-11) on epithelial cell differentiation using adult mouse-derived primary skin epithelial cell (MPSEC) cultures and hair growth using hair follicle organ cultures. Only Wnt-10b showed evident promotion of epithelial cell differentiation and hair shaft growth, in contrast to Wnt-3a, 5a, and 11. Our results suggest that Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. (c) 2007 Elsevier Inc. All rights reserved.