Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA.
Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA.
复制标题
间质性肉芽肿性皮炎伴组织细胞假玫瑰花结：皮肤疏螺旋体病的一种新的组织病理学模式。
DOI：
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复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
L. Requena
中科院分区：
文献类型：
--
作者：
Carmen Moreno;H. Kutzner;G. Palmedo;E. Goerttler;L. Carrasco;L. Requena
背景
伯氏疏螺旋体感染的皮肤表现包括早期慢性游走性红斑和晚期慢性萎缩性肢端皮炎病变。
目的
我们描述了11例特殊的皮肤表现和独特的组织病理学结果的结果B burgdorferi感染。
方法
本研究包括11例经聚合酶链反应或聚合酶链反应酶联免疫吸附试验在皮肤病变中检测到B伯氏菌的患者。我们分析了所有患者的临床资料和组织病理学结果。还对炎性浸润进行了组织化学研究。
结果
大多数患者表现出特殊的临床背景硬斑病，少数病例表现出慢性游走性红斑的特征性外观，而不是慢性萎缩性肢端皮炎，正如预期的B burgdorferi感染的晚期。所有病例的组织病理学结果相似，包括间质性炎性浸润，主要由分散在真皮胶原束中的组织细胞组成，以及小假玫瑰花结形成的局灶性区域，其特征在于小组织细胞放射状分布在厚胶原束周围。在某些情况下，也有一些浆细胞与组织细胞混合。
结论
在B burgdorferi感染的中期皮肤病变中，可能会出现临床表现与硬斑病相似、组织病理学特征与间质型环状肉芽肿非常相似的皮肤病变。这些临床和组织病理学表现代表了一系列以前未被表征为B burgdorferi感染的皮肤表现的结果。
BACKGROUND
The cutaneous manifestations of Borrelia burgdorferi infection include an early phase of erythema chronicum migrans and a late stage of acrodermatitis chronica atrophicans lesions.
OBJECTIVE
We describe 11 patients with peculiar cutaneous manifestations and distinctive histopathologic findings as the result of B burgdorferi infection.
METHODS
Eleven patients with B burgdorferi detected by polymerase chain reaction or polymerase chain reaction enzyme-linked immunosorbent assay in their cutaneous lesions were included in this study. We analyzed clinical data and histopathologic findings in all patients. The inflammatory infiltrate was also immunohistochemically investigated.
RESULTS
Most patients showed a peculiar clinical setting of morphea, and a few cases presented the characteristic appearance of erythema chronicum migrans instead of acrodermatitis chronica atrophicans, as would be expected in a late phase of B burgdorferi infection. The histopathologic findings were similar in all cases and consisted of an interstitial inflammatory infiltrate mostly composed of histiocytes dispersed among the collagen bundles of the dermis and focal areas of small pseudorosette formation, characterized by small histiocytes radially disposed around thick collagen bundles. In some cases there were also a few plasma cells intermingled with the histiocytes.
CONCLUSION
Cutaneous lesions with clinical appearance similar to that of morphea and histopathologic features closely resembling those of the interstitial type of granuloma annular may be seen in intermediate-stage cutaneous lesions of B burgdorferi infection. These clinical and histopathologic findings represent a constellation of findings that have not been previously characterized as a cutaneous manifestation of B burgdorferi infection.
美国慢性萎缩性肢端皮炎：六例临床和组织病理学特征。
DOI：
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发表时间：
1994
期刊：
Cutis; cutaneous medicine for the practitioner
影响因子：
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作者：
DiCaudo,DJ;Su,WP;Marshall,WF;Malawista,SE;Barthold,S;Persing,DH
通讯作者：
Persing,DH
诊断早期莱姆病。
DOI：
10.1016/0002-9343(85)90432-2
发表时间：
1985
期刊：
The American journal of medicine
影响因子：
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作者：
Shrestha,M;Grodzicki,RL;Steere,AC
通讯作者：
Steere,AC