Sensory Loss and Risk of Dementia
Sensory Loss and Risk of Dementia
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DOI：
10.1177/10738584221126090
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发表时间：
2022-09
期刊：
影响因子：
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通讯作者：
M. Lad;W. Sedley;T. Griffiths
中科院分区：
文献类型：
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作者：
M. Lad;W. Sedley;T. Griffiths
嗅觉、视觉和听觉的感觉丧失是痴呆症的危险因素，但原因尚不清楚。这篇综述介绍了神经生物学证据连接每一种感觉的方式，以特定的痴呆症，并探讨潜在的机制。嗅觉缺陷可能与阿尔茨海默病和帕金森病引起的嗅觉系统的直接神经病理学变化有关，并且可能是疾病严重程度的标志。视力缺陷可能会通过降低对痴呆症的恢复力来增加脆弱个体患痴呆症的风险。听力缺陷可能通过多种机制表明对阿尔茨海默病的易感性。更一般地说，感觉障碍可能与对抗痴呆症的恢复力相关的因素有关。需要进一步的研究来梳理出感觉障碍的具体和协同作用。研究感觉丧失与神经退行性生物标志物的关系对于阐明相关机制是必要的。这可以为有痴呆风险的人提供新的监测和管理策略。
Sensory loss in olfaction, vision, and hearing is a risk factor for dementia, but the reasons for this are unclear. This review presents the neurobiological evidence linking each sensory modality to specific dementias and explores the potential mechanisms underlying this. Olfactory deficits can be linked to direct neuropathologic changes in the olfactory system due to Alzheimer disease and Parkinson disease, and may be a marker of disease severity. Visual deficits potentially increase dementia risk in a vulnerable individual by reducing resilience to dementia. Hearing deficits may indicate a susceptibility to Alzheimer disease through a variety of mechanisms. More generally, sensory impairment could be related to factors associated with resilience against dementia. Further research is needed to tease out the specific and synergistic effects of sensory impairment. Studying sensory loss in relation to neurodegenerative biomarkers is necessary to clarify the mechanisms involved. This could produce new monitoring and management strategies for people at risk of dementia.