Effect of topiramate on attention
Effect of topiramate on attention
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DOI：
10.1016/s0920-1211(96)01015-7
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发表时间：
1997-04-01
影响因子：
2.2
通讯作者：
Harden, C
中科院分区：
文献类型：
--
作者：
Burton, LA;Harden, C
注意力受损是抗癫痫药物经常报道的副作用，也是癫痫常见的一般主诉。因此，评估新药物对注意力过程的影响非常重要。在 3 个月的时间内，每周对 10 名接受托吡酯治疗的受试者进行注意力评估。注意力是通过数字广度（一种广泛使用的注意力指数）来评估的。构建并随机化不同的编号序列以允许重复使用。九名受试者中有四名显示托吡酯剂量与每周测量的前指跨度之间存在显着相关性，因此较高剂量与较差注意力相关。这些受试者和那些没有表现出显着关系的受试者之间的平均托吡酯剂量和癫痫发作减少没有差异。 (C) 1997 Elsevier Science B.V.
Impaired attention is a frequently reported side effect of anti-epileptic medication, as well as a frequent general complaint of epilepsy. It is thus important to evaluate the effect of new medications on attention processes. Attention was assessed weekly in ten subjects receiving topiramate over a 3 month period. Attention was evaluated with digit span, a widely used index of attention. Different number sequences were constructed and randomized to allow for repeated use. Four of nine subjects showed significant correlations between topiramate dosage and forward digit span measured weekly, such that higher dosage was associated with poorer attention. The average topiramate dosage and seizure reduction did not differ between these subjects and those who did not show a significant relationship. (C) 1997 Elsevier Science B.V.