Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer
Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer
复制标题
基于 pH 响应配位键的转铁蛋白启发的载体可对抗多重耐药乳腺癌
DOI：
10.1016/j.biomaterials.2016.11.001
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发表时间：
2017-01-01
期刊：
影响因子：
14
通讯作者：
Jiang, Hu-Lin
中科院分区：
文献类型：
--
作者：
He, Yu-Jing;Xing, Lei;Jiang, Hu-Lin
A novel biomimetic drug delivery system (BDDS) inspired by the pH-dependent ferric ion-transport and release manner of transferrin (Tf) was developed for combating multidrug-resistant breast cancer. Tf-inspired carrier was synthesized by modifying bovine serum albumin (BSA) with histamine (HA) through amide reaction to provide superior specific coordination sites for ferric ion-drug complexes, and self-assembled into nanoparticles (NPs) induced by coordination bond. Tf-inspired NPs were prepared via environment-friendly method, and well redispersed in saline after lyophilization. When internalized into tumor cells by SPARC (secreted protein acidic and rich in cysteine) mediated endocytosis, Tf-inspired NPs bypassed and decreased the P-glycoprotein-mediated drug efflux and led to more effective treatment of multidrug-resistant breast cancer compared with free drugs both in vitro and in vivo due to the enhanced cellular uptake and rapid pH-responsive drug release. Moreover, Tf-inspired NPs exhibited good biocompatibility and low systemic toxicity. Thus, our results demonstrate that Tf-inspired NPs based on coordination bond represent as a smart drug delivery strategy to combat multidrug-resistant cancer and have great potential for clinical applications in cancer therapy. (C) 2016 Elsevier Ltd. All rights reserved.
