Gradient nanostructures for interfacing microfluidics and nanofluidics
Gradient nanostructures for interfacing microfluidics and nanofluidics
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DOI：
10.1063/1.1515115
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发表时间：
2002-10-14
影响因子：
4
通讯作者：
Chou, SY
中科院分区：
文献类型：
--
作者：
Cao, H;Tegenfeldt, JO;Chou, SY
由于聚合物的必要拉伸引起的陡峭的熵垒，很难将长的基因组DNA分子直接从宏观世界引入纳米尺度的流体通道中。我们提出了一个非常简单的技术，使用光刻制造连续的空间梯度结构，顺利缩小从微米到纳米长度尺度的体积的横截面，大大降低了当地的熵障碍纳米通道进入。这种衍射梯度光刻技术对于微纳全分析系统的制作是非常有价值的。(C)2002年美国物理学会。
It is difficult to introduce long genomic DNA molecules into nanometer scale fluidic channels directly from the macroscale world because of the steep entropic barrier caused by necessary stretching of the polymer. We present a very simple technique using optical lithography to fabricate continuous spatial gradient structures which smoothly narrow the cross section of a volume from the micron to the nanometer length scale, greatly reducing the local entropic barrier to nanochannel entry. This technique, diffraction gradient lithography, can be very valuable for the fabrication of micro/nano total analysis systems. (C) 2002 American Institute of Physics.