Regenerative Therapies for Spinal Cord Injury
Regenerative Therapies for Spinal Cord Injury
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DOI：
10.1089/ten.teb.2019.0182
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发表时间：
2019-10-23
影响因子：
6.4
通讯作者：
Seidlits, Stephanie K.
中科院分区：
文献类型：
--
作者：
Ashammakhi, Nureddin;Kim, Han-Jun;Seidlits, Stephanie K.
脊髓损伤（SCI）是一个严重的问题，主要影响年轻人和中年人在其发病。到目前为止，还没有开发出有效的再生治疗方法。在过去的十年中，研究人员在干细胞技术，生物材料，纳米技术和免疫工程方面取得了重大进展，这些技术可以应用于脊髓的再生疗法。尽管使用特定细胞疗法的临床试验结果已被证明是安全的，但其疗效尚未得到证实。SCI的病理生理学是多方面的、复杂的，尚未得到充分理解。因此，可能需要同时利用多种方法的组合疗法来实现令人满意的结果。虽然已经探索了生物材料与药物或细胞的组合，但很少有研究以系统的方式将这些方式结合起来。对于大多数策略，临床翻译将通过使用微创治疗来促进，这是本次审查的重点。此外，这篇综述讨论了先前探索的旨在促进SCI后神经再生和神经保护的治疗方法，同时强调了目前的挑战和未来的方向。影响声明到目前为止，还没有有效的治疗方法可以再生脊髓损伤后。尽管在过去的十年中，生物工程和再生医学在临床前取得了重大进展，但这些进展尚未转化为脊髓损伤的有效临床治疗。本文综述了微创治疗，提供了广泛的背景以及最新的技术发展和当前的临床试验。这篇综述是一个全面的资源，为研究人员致力于脊髓损伤的再生疗法，将有助于指导未来的创新。
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged adults at its onset. To date, no effective regenerative treatment has been developed. Over the last decade, researchers have made significant advances in stem cell technology, biomaterials, nanotechnology, and immune engineering, which may be applied as regenerative therapies for the spinal cord. Although the results of clinical trials using specific cell-based therapies have proven safe, their efficacy has not yet been demonstrated. The pathophysiology of SCI is multifaceted, complex and yet to be fully understood. Thus, combinatorial therapies that simultaneously leverage multiple approaches will likely be required to achieve satisfactory outcomes. Although combinations of biomaterials with pharmacologic agents or cells have been explored, few studies have combined these modalities in a systematic way. For most strategies, clinical translation will be facilitated by the use of minimally invasive therapies, which are the focus of this review. In addition, this review discusses previously explored therapies designed to promote neuroregeneration and neuroprotection after SCI, while highlighting present challenges and future directions. Impact Statement To date there are no effective treatments that can regenerate the spinal cord after injury. Although there have been significant preclinical advances in bioengineering and regenerative medicine over the last decade, these have not translated into effective clinical therapies for spinal cord injury. This review focuses on minimally invasive therapies, providing extensive background as well as updates on recent technological developments and current clinical trials. This review is a comprehensive resource for researchers working towards regenerative therapies for spinal cord injury that will help guide future innovation.