Coding of task reward value in the dorsal raphe nucleus.
Coding of task reward value in the dorsal raphe nucleus.
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DOI：
10.1523/jneurosci.0015-10.2010
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发表时间：
2010-05-05
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影响因子：
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通讯作者：
Nakamura K
中科院分区：
文献类型：
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作者：
Bromberg-Martin ES;Hikosaka O;Nakamura K
中缝背核及其释放血清素的神经元被认为可以调节动机和寻求奖励。已知这些神经元在动机行为期间是活跃的，但控制其活动的基本原理尚不清楚。在这里，我们展示了一组中缝背神经元以系统的方式编码行为任务，跟踪即将到来的奖励的进展。我们分析了动物执行两项奖励导向的扫视任务时记录的中缝背神经元活动。行为任务期间神经元的强直活动水平与其奖励相关线索和结果的编码之间存在很强的相关性。在任务期间处于紧张兴奋状态的神经元主要携带积极的奖励信号。在任务期间受到紧张性抑制的神经元主要携带负奖励信号。在任务期间没有改变其强直活动水平的神经元的奖励信号较弱，没有积极或消极方向的倾向。这种形式的相关任务和奖励编码解释了我们任务中中缝背侧反应模式的大部分系统变异。神经活动的一小部分反映了奖励传递的检测。我们的数据表明，中缝背核根据未来的动机结果对行为任务的参与进行编码。
The dorsal raphe nucleus and its serotonin-releasing neurons are thought to regulate motivation and reward-seeking. These neurons are known to be active during motivated behavior, but the underlying principles that govern their activity are unknown. Here we show that a group of dorsal raphe neurons encode behavioral tasks in a systematic manner, tracking progress toward upcoming rewards. We analyzed dorsal raphe neuron activity recorded while animals performed two reward-oriented saccade tasks. There was a strong correlation between the tonic activity level of a neuron during behavioral tasks and its encoding of reward-related cues and outcomes. Neurons that were tonically excited during the task predominantly carried positive reward signals. Neurons that were tonically inhibited during the task predominantly carried negative reward signals. Neurons that did not change their tonic activity levels during the task had weak reward signals with no tendency for a positive or negative direction. This form of correlated task and reward coding accounted for the majority of systematic variation in dorsal raphe response patterns in our tasks. A smaller component of neural activity reflected detection of reward delivery. Our data suggest that the dorsal raphe nucleus encodes participation in a behavioral task in terms of its future motivational outcomes.