Epistasis and the release of genetic variation during long-term selection
Epistasis and the release of genetic variation during long-term selection
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DOI：
10.1038/ng1761
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发表时间：
2006-04-01
期刊：
影响因子：
30.8
通讯作者：
Andersson, L
中科院分区：
文献类型：
--
作者：
Carlborg, Ö;Jacobsson, L;Andersson, L
这是模型生物和农业物种中的长期选择如何导致明显的表型变化，而不会耗尽所选特征的遗传变异。在这里，我们表明，鸡肉在四个相互作用基因座的遗传网络中，显然是一个显然是生长的主要基因座的遗传结构。该径向网络中的相互作用介导了比单位级模型所预测的要大得多的选择响应。
It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.