Differential expression of hsp90, gelsolin and gst-pi in human gastric-carcinoma cell-lines.
Differential expression of hsp90, gelsolin and gst-pi in human gastric-carcinoma cell-lines.
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DOI：
10.3892/ijo.5.6.1347
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发表时间：
1994-12
影响因子：
5.2
通讯作者：
S. Moriya;K. Yanagihara;H. Fujita;N. Kuzumaki
中科院分区：
文献类型：
--
作者：
S. Moriya;K. Yanagihara;H. Fujita;N. Kuzumaki
我们分析了各种人胃癌细胞系和正常胃粘膜中产生的蛋白质。HSP 90在8个胃癌细胞系中表达增加。在7个胃癌细胞系中凝溶胶蛋白含量下调。此外，GST-pi的产生在低分化腺癌细胞系和两个硬癌细胞系中增加。这些结果提示，HSP 90的表达增加和gelsolin的表达下调在胃癌的发生中起重要作用，而GST-pi的大量表达与某些硬癌的独特行为有关。
We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly differentiated adenocarcinoma cell line and two scirrhous gastric carcinoma cell lines. These results suggest that increased production of HSP90 and down-regulation of gelsolin play an important role in gastric carcinogenesis, and that abundant production of GST-pi is related to unique behavior of some scirrhous gastric carcinomas.