Sex steroid hormones-related structural plasticity in the human hypothalamus
Sex steroid hormones-related structural plasticity in the human hypothalamus
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DOI：
10.1016/j.neuroimage.2009.11.074
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发表时间：
2010-04-01
期刊：
影响因子：
5.7
通讯作者：
Prevot, Vincent
中科院分区：
文献类型：
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作者：
Baroncini, Marc;Jissendi, Patrice;Prevot, Vincent
我们利用代谢磁共振成像(MRI)研究了人工月经周期对年轻女性大脑结构和活动的影响。我们发现，在小剂量口服避孕药联合使用期间，下丘脑-垂体-性腺轴的激活与女性下丘脑的瞬时微结构和代谢变化有关，但与丘脑的短暂微结构和代谢变化无关，通过水扩散和质子磁共振光谱测量进行评估。我们的结果为性类固醇激素调节中枢效应的机制提供了神经解剖学方面的见解，并提高了有趣的可能性，即神经内分泌脑的特定区域使用卵巢周期依赖的可塑性来控制人类的生殖。这些基于MRI的生理学研究可能为开发新的诊断和治疗策略铺平道路，以治疗人类综合征中生殖能力的中枢丧失，如下丘脑闭经。(C)2009 Elsevier Inc.保留所有权利。
We investigated the effects of an artificial menstrual cycle on brain structure and activity in young women using metabolic magnetic resonance imaging (MRI). We show that the activation of the hypothalamo-pituitary-gonadal axis during the pill-free interval of low-dose combined oral contraceptive use is associated with transient microstructural and metabolic changes in the female hypothalamus but not in the thalamus, a brain structure unrelated to reproductive control, as assessed by water diffusion and proton magnetic resonance spectra measurements. Our results provide neuroanatomical insights into the mechanism by which sex steroid hormones mediate their central effects and raise the intriguing possibility that specific regions of the neuroendocrine brain use ovarian cycle-dependent plasticity to control reproduction in humans. These MRI-based physiological studies may pave the way for the development of new diagnostic and treatment strategies in the central loss of reproductive competence in human syndromes, such as hypothalamic amenorrhea. (C) 2009 Elsevier Inc. All rights reserved.