Total synthesis of (+)-cyanthiwigin U
Total synthesis of (+)-cyanthiwigin U
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DOI：
10.1021/ja0509836
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发表时间：
2005-04-20
影响因子：
15
通讯作者：
Phillips, AJ
中科院分区：
文献类型：
--
作者：
Pfeiffer, MWB;Phillips, AJ
三环萜烯cythiwigin U的简明全合成经过12步完成，总收率为17%。合成的关键步骤是双向串联复分解反应，该反应从容易获得的双环[2.2.2]辛烯形成环庚[e]茚核心。
A concise total synthesis of the tricyclic terpene cyanthiwigin U has been accomplished in 12 steps and 17% overall yield. The key step of the synthesis is a two-directional tandem metathesis reaction that forms the cyclohepta[e]indene core from a readily available bicyclo[2.2.2]octene.