Gonadal hormones and cognitive aging: a midlife perspective.
Gonadal hormones and cognitive aging: a midlife perspective.
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DOI：
10.2217/whe.10.87
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
Henderson VW
中科院分区：
文献类型：
--
作者：
Henderson VW
性腺类固醇会影响多种大脑过程。与更年期相关的荷尔蒙变化的认知后果具有科学意义和公共卫生意义。自然更年期是一个正常的生理过程，只有通过观察研究才能直接研究。同样，人类的外科更年期很少直接服从于实验研究。因此，关于认知结果的因果关系很难推断。墨尔本女性中年健康项目、全国女性健康研究和其他中年队列的横向和纵向研究结果表明，自然更年期转变的认知后果可能很小，至少在中年和情节记忆方面是如此，这是一个关键的认知领域，数据最可靠。与绝经前相比，自然绝经后不久的中年情景记忆表现相似，中年时的血清雌二醇浓度是无关的情景记忆表现。自然绝经对其他认知领域的影响，手术绝经的认知后果，以及中年激素暴露的晚年认知后果，还不太清楚，值得继续研究。
Gonadal steroids affect a variety of brain processes. Cognitive consequences of hormonal changes associated with menopause are of scientific interest and of public heath relevance. Natural menopause is a normal physiological process that can be directly studied only through observational research. Similarly, surgical menopause in humans is rarely directly amenable to experimental research. Causality with respect to cognitive outcomes is therefore difficult to infer. Cross-sectional and longitudinal findings from the Melbourne Women’s Midlife Health Project, the Study of Women’s health Across the Nation, and other midlife cohorts suggest that cognitive consequences of the natural menopausal transition are probably small, at least during midlife and at least for episodic memory, a key cognitive domain for which data are the most robust. Midlife episodic memory performance is similar shortly after natural menopause compared to shortly before, and serum estradiol concentration in midlife is unassociated episodic memory performance. Effects of natural menopause on other cognitive domains, cognitive consequences of surgical menopause, and late-life cognitive consequences of midlife hormonal exposures are less well understood and merit continued study.