Increased superoxide generation is associated with pulmonary hypertension in fetal lambs - A role for NADPH oxidase
Increased superoxide generation is associated with pulmonary hypertension in fetal lambs - A role for NADPH oxidase
复制标题
DOI：
10.1161/01.res.0000063424.28903.bb
复制
发表时间：
2003-04-04
影响因子：
20.1
通讯作者：
Black, SM
中科院分区：
文献类型：
--
作者：
Brennan, LA;Steinhorn, RH;Black, SM
子宫内动脉导管结扎可引起胎儿和新生羔羊肺动脉高压和血管重构。然而，产生这些血管变化的机制还没有很好的定义。由于活性氧（ROS）被认为是平滑肌细胞增殖的介质，我们假设ROS的形成增加可能与子宫内导管结扎后肺动脉高压的病理生理有关。使用乙锭荧光，我们证明了与对照肺相比，导管结扎9天后超氧化物水平增加（P
Ligation of the ductus arteriosus in utero produces pulmonary hypertension and vascular remodeling in fetal and newborn lambs. However, the mechanisms producing these vascular changes are not well defined. Because reactive oxygen species (ROS) have been implicated as mediators of smooth muscle cell proliferation, we hypothesized that increased formation of ROS may be involved in the pathophysiology of pulmonary hypertension after in utero ductal ligation. Using ethidium fluorescence, we demonstrated an increase in superoxide levels after 9 days of ductal ligation compared with control lungs (P