Hyrtimomines A-C, New Heteroaromatic Alkaloids from a Sponge Hyrtios sp.
Hyrtimomines A-C, New Heteroaromatic Alkaloids from a Sponge Hyrtios sp.
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DOI：
10.1021/ol400687b
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发表时间：
2013-04-19
期刊：
影响因子：
5.2
通讯作者：
Kobayashi, Jun'ichi
中科院分区：
文献类型：
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作者：
Momose, Rei;Tanaka, Naonobu;Kobayashi, Jun'ichi
从冲绳海绵Hyrtios sp.中分离得到3个新生物碱，命名为Hyrtimomines A-C（1-3），通过波谱分析和苯甘氨酸甲酯（PGME）法鉴定了化合物1-3的结构。Hyrtimomine A（1）和B（2）是具有稠合六环6/5/6/6/7/5系统的杂芳族生物碱，而Hyrtimomine C（3）是由羟基吲哚和氮杂卓-羟基吲哚部分组成的生物碱。Hyrtimomine A（1）对KB和L1210细胞具有细胞毒作用。
Three new alkaloids, hyrtimomines A-C (1-3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1-3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids possessing a fused hexacyclic 6/5/6/6/7/5 ring system, while hyrtimomine C (3) is an alkaloid consisting of hydroxyindole and azepino-hydroxyindole moieties. Hyrtimomine A (1) exhibited cytotoxicity against KB and L1210 cells.