Increased midbrain gray matter in Tourette's syndrome
Increased midbrain gray matter in Tourette's syndrome
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DOI：
10.1002/ana.20765
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发表时间：
2006-02-01
影响因子：
11.2
通讯作者：
Hallett, M
中科院分区：
文献类型：
--
作者：
Garraux, G;Goldfine, A;Hallett, M
目的：探讨妥瑞氏综合征（TS）的大脑结构。方法：对31例TS患者和31例对照组进行高分辨率mri体素形态学研究。结果：31例TS患者以左中脑灰质增多为主。解释：这一结果构成了支持Devinsky假说（Devinsky O. Gilles de la Tourette syndrome的神经解剖学）的有力而直接的证据。可能涉及中脑。Arch Neurol 1983；40:508514)据此，中脑紊乱在TS中起着重要的致病作用。
Objective: To investigate cerebral structure in Tourette's syndrome (TS).Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls.Results: Increased gray matter mainly in the left mesencephalon in 31 TS patients.Interpretation: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508514) according to which midbrain disturbances play an important pathogenic role in TS.